Effects of fibre-enriched diets on tissue lipid profiles of MSG obese rats

• Published in: Food and chemical toxicology Vol. 50; no. 11; pp. 4062 - 4067
• Main Authors: Rotimi, O.A., Olayiwola, I.O., Ademuyiwa, O., Balogun, E.A.
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 01.11.2012; Elsevier
• Subjects: animal models; Animals; Biological and medical sciences; cassava; cholesterol; Cholesterol - blood; corn; diet; Dietary Fiber - pharmacology; Disease Models, Animal; Dyslipidemia; Dyslipidemias - chemically induced; erythrocytes; feed intake; Fibre; heart; HMG-CoA reductase; Hydroxymethylglutaryl CoA Reductases - metabolism; hyperlipidemia; Kidney - drug effects; Kidney - metabolism; kidneys; Lipid Metabolism - drug effects; liver; Liver - drug effects; Liver - metabolism; Male; Manihot esculenta; Medical sciences; Metabolic diseases; monosodium glutamate; MSG; Myocardium - metabolism; Obesity; Obesity - chemically induced; Obesity - diet therapy; Obesity - metabolism; Organ Size - drug effects; phospholipids; Phospholipids - metabolism; Rats; Sodium Glutamate - toxicity; Toxicology; triacylglycerols; Triglycerides - blood; Weight Gain; Zea mays; MSG; Obesity; Fibre; HMG-CoA reductase; Dyslipidemia; Rat; EC 1.1.1.88; Lipids; Tissue; Dyslipemia; Nutritional status; Nutrition; Enzyme; EC 1.1.1.34; Biochemical compound; Rodentia; Nutrition disorder; Metabolic diseases; Feeding; Vertebrata; Mammalia; Diet; Animal; Hydroxymethylglutaryl-CoA reductase; Oxidoreductases
• ISSN: 0278-6915; 1873-6351
• DOI: 10.1016/j.fct.2012.08.001

► MSG induced obesity in rats. ► Hypolipidemic effects of some fibre-enriched diets was investigated in obese rats. ► The diets reversed the obesity induced hyperlipidemia in the rats. ► Obesity could be attenuated by consumption of fibre-enriched diets. In order to investigate the influence of some fibre-enriched diets on tissue lipids in an animal model of obesity induced by the administration of monosodium glutamate (MSG), obese rats were fed diets containing 30% of Acha, Cassava, Maize and Plantain for five weeks and weight gain, feed intake and lee index were recorded. The lipid profiles of plasma, erythrocytes, kidney, heart and liver as well as hepatic 3-hydroxyl-3-methylglutaryl-CoA (HMG-CoA) reductase activity were measured. The diets significantly (p<0.05) reduced weight gain and lee index in the obese rats. Obesity-induced increase in plasma and erythrocytes lipid levels was significantly (p<0.05) reduced by these diets. MSG-induced obesity also resulted in a significant increase (p<0.05) in hepatic cholesterol level which was reduced by the diets. MSG-obesity was characterised by a significant (p<0.05) increase in cholesterol, triacylglycerol and phospholipids in kidney and this was reversed by the diets except Maize which did not reverse the increased cholesterol level. Only Acha reversed the obesity-induced increase in heart cholesterol and phospholipids. The increased activity of hepatic HMG-CoA reductase associated with obesity was also significantly (p<0.05) reduced by the diets. In conclusion, dyslipidemia associated with MSG-induced obesity could be attenuated by consumption of fibre-enriched diets.