Seizures associated with ofloxacin therapy

We describe four patients who had seizures while receiving ofloxacin; no other causes were evident. Common factors among all patients included advanced age and use of a high-dose regimen. The renal insufficiency of three patients and the timing of the seizures implicate accumulation of ofloxacin as...

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Bibliographic Details
Published inClinical infectious diseases Vol. 21; no. 6; p. 1504
Main Authors Traeger, S M, Bonfiglio, M F, Wilson, J A, Martin, B R, Nackes, N A
Format Journal Article
LanguageEnglish
Published United States 01.12.1995
Subjects
Aged
Aged, 80 and over
Female
Haemophilus Infections - complications
Haemophilus Infections - drug therapy
Haemophilus influenzae
Humans
Klebsiella Infections - drug therapy
Klebsiella pneumoniae
Male
Middle Aged
Ofloxacin - adverse effects
Ofloxacin - therapeutic use
Pneumonia - drug therapy
Seizures - chemically induced
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Summary:We describe four patients who had seizures while receiving ofloxacin; no other causes were evident. Common factors among all patients included advanced age and use of a high-dose regimen. The renal insufficiency of three patients and the timing of the seizures implicate accumulation of ofloxacin as a contributing factor. Other potentially related factors included electrolyte abnormalities and prior neurological insult. Improved awareness of and further investigation into the neurotoxic effects of ofloxacin may enhance its safe use.
ISSN:1058-4838
DOI:10.1093/clinids/21.6.1504