How hepatitis C virus invades hepatocytes: The mystery of viral entry

Hepatitis C virus(HCV)infection is a global health problem,with an estimated 170 million people being chronically infected.HCV cell entry is a complex multi-step process,involving several cellular factors that trigger virus uptake into the hepatocytes.The high-density lipoprotein receptor scavenger...

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Bibliographic Details
Published inWorld journal of gastroenterology : WJG Vol. 20; no. 13; pp. 3457 - 3467
Main Author Zhu, Yong-Zhe
Format Journal Article
LanguageEnglish
Published United States Baishideng Publishing Group Co., Limited 07.04.2014
Subjects
Animals
Antiviral Agents - therapeutic use
CD36 Antigens - metabolism
Cell Membrane - virology
Claudin-1 - metabolism
Endocytosis
Endosomes
entry
Hepacivirus - physiology
Hepatitis
Hepatitis C - physiopathology
Hepatocytes
Hepatocytes - virology
Humans
Liver - pathology
Occludin - metabolism
Phenylenediamines - pharmacology
Receptor
Receptor Protein-Tyrosine Kinases - metabolism
Sulfonamides - pharmacology
Tetraspanin 28 - metabolism
Topic Highlight
virus
Virus Internalization
Host kinase
Hepatocytes
Hepatitis C virus
Receptor
Antiviral target
Virus entry
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Summary:Hepatitis C virus(HCV)infection is a global health problem,with an estimated 170 million people being chronically infected.HCV cell entry is a complex multi-step process,involving several cellular factors that trigger virus uptake into the hepatocytes.The high-density lipoprotein receptor scavenger receptor class B type I,tetraspanin CD81,tight junction protein claudin-1,and occludin are the main receptors that mediate the initial step of HCV infection.In addition,the virus uses cell receptor tyrosine kinases as entry regulators,such as epidermal growth factor receptor and ephrin receptor A2.This review summarizes the current understanding about how cell surface molecules are involved in HCV attachment,internalization,and membrane fusion,and how host cell kinases regulate virus entry.The advances of the potential antiviral agents targeting this process are introduced.
Bibliography:Yong-Zhe Zhu;Xi-Jing Qian;Ping Zhao;Zhong-Tian Qi;Department of Microbiology,Shanghai Key Laboratory of Medical Biodefense,Second Military Medical University
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Author contributions: All authors contributed to this work.
Telephone: +86-21-81870988 Fax: +86-21-81870988
Correspondence to: Zhong-Tian Qi, PhD, Department of Microbiology, Shanghai Key Laboratory of Medical Biodefense, Second Military Medical University, 800 Xiangyin Road, Shanghai 200433, China. qizt@smmu.edu.cn
ISSN:1007-9327
2219-2840
2219-2840
DOI:10.3748/wjg.v20.i13.3457