The Nongenomic Effects of Progesterone in Repressing iNOS Activation through P38MAPK Pathways in Gonococci-Infected Polymorphonuclear Leukocytes and the Clinical Significance

• Published in: Journal of Huazhong University of Science and Technology. Medical sciences Vol. 30; no. 1; pp. 119 - 125
• Main Author: 陈嵘祎 涂亚庭 林加西 佘惟槟 李娟 吴志洪 许莉 陈宏翔
• Format: Journal Article
• Language: English
• Published: Heidelberg Huazhong University of Science and Technology 01.02.2010; Guangdong Medical College,Zhanjiang 524023,China%Guangdong Medical College,Zhanjiang 524023,China%Department of Dermatology,Union Hospital,Tongli Medical College,Huazhong University of Science and Technology,Wuhan 430022,China; Department of Dermatology,Union Hospital,Tongli Medical College,Huazhong University of Science and Technology,Wuhan 430022,China
• Subjects: Adolescent; Adult; Cells, Cultured; Female; Gonorrhea - microbiology; Humans; Male; MAP Kinase Signaling System; Medicine; Medicine & Public Health; Neisseria gonorrhoeae - growth & development; Neisseria gonorrhoeae - isolation & purification; Neutrophils - cytology; Neutrophils - metabolism; Neutrophils - microbiology; Nitric Oxide - metabolism; Nitric Oxide Synthase Type II - metabolism; p38 Mitogen-Activated Protein Kinases - metabolism; Progesterone - pharmacology; Young Adult; asymptomatic infection; nongenomic effects; gonococcus; progesterone; inducible nitric oxide synthase
• ISSN: 1672-0733; 1993-1352
• DOI: 10.1007/s11596-010-0122-4

Progesterone has nongenomic effects on inducible nitric oxide synthase(iNOS),which is mediated by mitogen activated protein kinase(MAPK)pathways.This effect is supposed to have some potential association with asymptomatic gonococcal infections in women by immunological depression.In this study,polymorphonuclear leukocytes(PMNs)challenged by gonococci were used to study the nongenomic effects of progesterone.The activation of iNOS was assessed by measuring [3H] L-arginine converses to [3H] L-citrulline,and t...