Systemic immune-inflammation index for predicting prognosis of colorectal cancer

AIM To investigate the clinical significance of preoperative systemic immune-inflammation index(SII) in patients with colorectal cancer(CRC). METHODS A retrospective analysis of 1383 cases with CRC was performed following radical surgery. SII was calculated with the formula SII =(P × N)/L, where P,...

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Published inWorld journal of gastroenterology : WJG Vol. 23; no. 34; pp. 6261 - 6272
Main Authors Chen, Jian-Hui, Zhai, Er-Tao, Yuan, Yu-Jie, Wu, Kai-Ming, Xu, Jian-Bo, Peng, Jian-Jun, Chen, Chuang-Qi, He, Yu-Long, Cai, Shi-Rong
Format Journal Article
LanguageEnglish
Published United States Baishideng Publishing Group Inc 14.09.2017
Subjects
Blood Platelets - immunology
Chemotherapy, Adjuvant
Colon - pathology
Colon - surgery
Colorectal Neoplasms - blood
Colorectal Neoplasms - immunology
Colorectal Neoplasms - mortality
Colorectal Neoplasms - therapy
Disease-Free Survival
Female
Humans
Inflammation - blood
Inflammation - immunology
Inflammation - mortality
Inflammation - therapy
Lymphocyte Count
Lymphocytes - immunology
Male
Middle Aged
Neoplasm Staging
Neutrophils - immunology
Platelet Count
Preoperative Period
Prognosis
Rectum - pathology
Rectum - surgery
Retrospective Cohort Study
Retrospective Studies
Risk Assessment - methods
Neutrophil-lymphocyte ratio
Platelet-lymphocyte ratio
Prognosis
Colorectal cancer
Systemic immune-inflammation index
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Summary:AIM To investigate the clinical significance of preoperative systemic immune-inflammation index(SII) in patients with colorectal cancer(CRC). METHODS A retrospective analysis of 1383 cases with CRC was performed following radical surgery. SII was calculated with the formula SII =(P × N)/L, where P, N, and L refer to peripheral platelet, neutrophil, and lymphocyte counts, respectively. The clinicopathological features and follow-up data were evaluated to compare SII with other systemic inflammation-based prognostic indices such as the neutrophil-lymphocyte ratio(NLR) and platelet-lymphocyte ratio(PLR) in patients with CRC.RESULTS The optimal cut-off point for SII was defined as 340. The overall survival(OS) and disease-free survival(DFS) were better in patients with low NLR, PLR, and SII(P < 0.05). The SII was an independent predictor of OS and DFS in multivariate analysis. The area under the receiver-operating characteristics(ROC) curve for SII(0.707) was larger than those for NLR(0.602) and PLR(0.566). In contrast to NLR and PLR, SII could effectively discriminate between the TNM subgroups. CONCLUSION SII is a more powerful tool for predicting survival outcome in patients with CRC. It might assist the identification of high-risk patients among patients with the same TNM stage.
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Correspondence to: Chuang-Qi Chen, MD, Gastrointestinal Surgery Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, Guangdong Province, China. chenchqi@mail.sysu.edu.cn
Supported by National Nature Science Foundation of China, No. 81672343 and No. 81372341; Guangdong Province Natural Science Fund of China, No. 2014A030310111; and Guangdong Science and Technology Plan Project of China, No. 2013B021800131and No. 201604020003.
Telephone: +86-87-755766-6211 Fax: +86-87-755766-6211
Author contributions: Chen JH and Zhai ET contributed equally to this study, and both conceptualized and designed the study, analyzed and interpreted the data, drafted the manuscript, and critically revised the manuscript for important intellectual content; Yuan YJ, Wu KM, Xu JB, Peng JJ and He YL participated in data acquisition and statistical analysis; Chen CQ and Cai SR supervised the whole study and monitored the standard surgical operations; all the authors took part in the surgical treatment of colorectal cancer.
ISSN:1007-9327
2219-2840
2219-2840
DOI:10.3748/wjg.v23.i34.6261