Advances in surgical management for locally recurrent rectal cancer: How far have we come?

• Published in: World journal of gastroenterology : WJG Vol. 23; no. 23; pp. 4170 - 4180
• Main Authors: Lee, Daniel Jin-Keat, Sagar, Peter M, Sadadcharam, Gaitri, Tan, Kok-Yang
• Format: Journal Article
• Language: English
• Published: United States Baishideng Publishing Group Inc 21.06.2017
• Subjects: Combined Modality Therapy; Humans; Margins of Excision; Minireviews; Neoplasm Recurrence, Local - surgery; Pelvic Exenteration; Postoperative Complications - surgery; Preoperative Period; Rectal Neoplasms - pathology; Rectal Neoplasms - surgery; Sacrum; Surgical Oncology - methods; Surgical Oncology - trends; Treatment Outcome; Watchful Waiting; Recurrent rectal cancer; Sacrectomy; Pelvic exenteration; Radical resection; Pelvic sidewall
• ISSN: 1007-9327; 2219-2840
• DOI: 10.3748/wjg.v23.i23.4170

Locally recurrent rectal cancer(LRRC) is a complex disease with far-reaching implications for the patient. Until recently, research was limited regarding surgical techniques that can increase the ability to perform an en bloc resection with negative margins. This has changed in recent years and therefore outcomes for these patients have improved. Novel radical techniques and adjuncts allow for more radical resections thereby improving the chance of negative resection margins and outcomes. In the past contraindications to surgery included anterior involvement of the pubic bone, sacral invasions above the level of S2/S3 and lateral pelvic wall involvement. However, current data suggests that previously unresectable cases may now be feasible with novel techniques, surgical approaches and reconstructive surgery. The publications to date have only reported small patient pools with the research conducted by highly specialised units. Moreover, the short and long-term oncological outcomes are currently under review. Therefore although surgical options for LRRC have expanded significantly, one should balance the treatment choices available against the morbidity associated with the procedure and select the right patient for it.