Antibiotic use in patients with COVID-19: a ‘snapshot’ Infectious Diseases International Research Initiative (ID-IRI) survey

• Published in: Journal of antimicrobial chemotherapy Vol. 75; no. 11; pp. 3386 - 3390
• Main Authors: Beović, Bojana, Doušak, May, Ferreira-Coimbra, João, Nadrah, Kristina, Rubulotta, Francesca, Belliato, Mirko, Berger-Estilita, Joana, Ayoade, Folusakin, Rello, Jordi, Erdem, Hakan
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.11.2020
• Subjects: Anti-Bacterial Agents - administration & dosage; Betacoronavirus; Coronavirus Infections - drug therapy; Coronavirus Infections - epidemiology; COVID-19; Drug Prescriptions - statistics & numerical data; Humans; Internationality; Original Research; Pandemics; Pneumonia, Viral - drug therapy; Pneumonia, Viral - epidemiology; SARS-CoV-2; Surveys and Questionnaires
• ISSN: 0305-7453; 1460-2091; 1460-2091
• DOI: 10.1093/jac/dkaa326

Abstract Background Antibiotics may be indicated in patients with COVID-19 due to suspected or confirmed bacterial superinfection. Objectives To investigate antibiotic prescribing practices in patients with COVID-19. Methods We performed an international web-based survey and investigated the pattern of antibiotic use as reported by physicians involved in treatment of COVID-19. SPSS Statistics version 25 was used for data analysis. Results The survey was completed by 166 participants from 23 countries and 82 different hospitals. Local guidelines for antibiotic use in COVID-19 patients were reported by 61.8% (n = 102) of participants and for 82.9% (n = 136) they did not differ from local community-acquired pneumonia guidelines. Clinical presentation was recognized as the most important reason for the start of antibiotics (mean score = 4.07 and SD = 1.095 on grading scale from 1 to 5). When antibiotics were started, most respondents rated as the highest the need for coverage of atypical pathogens (mean score = 2.8 and SD = 0.99), followed by Staphylococcus aureus (mean score = 2.67 and SD = 1.05 on bi-modal scale, with values 1 and 2 for disagreement and values 3 and 4 for agreement). In the patients on the ward, 29.1% of respondents chose not to prescribe any antibiotic. Combination of β-lactams and macrolides or fluoroquinolones was reported by 52.4% (n = 87) of respondents. In patients in the ICU, piperacillin/tazobactam was the most commonly prescribed antibiotic. The mean reported duration of antibiotic treatment was 7.12 (SD = 2.44) days. Conclusions The study revealed widespread broad-spectrum antibiotic use in patients with COVID-19. Implementation of antimicrobial stewardship principles is warranted to mitigate the negative consequences of antibiotic therapy.