Peculiarities of Histological Structure of Pulmonary Veins in Patients with Total Anomalous Pulmonary Venous Drainage as Morphological Substrates Relating to Formation of Postoperative Pulmonary Venous Obstruction

• Published in: Bulletin of experimental biology and medicine Vol. 168; no. 5; pp. 699 - 703
• Main Authors: Morozov, A. A., Movsesyan, R. R., Latypov, A. K., Martynova, O. A., Vasichkina, E. S.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.03.2020; Springer; Springer Nature B.V
• Subjects: Atrium; Autopsy; Biomedical and Life Sciences; Biomedicine; Cardiac Surgical Procedures - adverse effects; Case-Control Studies; Cell Biology; Etiology; Heart Atria - pathology; Heart Atria - surgery; Humans; Infant, Newborn; Internal Medicine; Laboratory Medicine; Morphology and Pathomorphology; Pathology; Postoperative Complications - etiology; Postoperative Complications - pathology; Postoperative Complications - physiopathology; Postoperative Period; Pulmonary Circulation - physiology; Pulmonary Veins - abnormalities; Pulmonary Veins - pathology; Pulmonary Veno-Occlusive Disease - etiology; Pulmonary Veno-Occlusive Disease - pathology; Pulmonary Veno-Occlusive Disease - physiopathology; Scimitar Syndrome - pathology; Scimitar Syndrome - physiopathology; Scimitar Syndrome - surgery; Veins; Veins & arteries; Wound drainage; total anomalous pulmonary venous drainage (TAPVD); histological structure; obstruction
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-020-04783-z

The histological and immunohistochemical methods were employed to examine the peculiarities of histological structure of pulmonary veins and left atrium of the heart in norm and in various types of total anomalous drainage of pulmonary veins. In contrast to normal pulmonary vein covered with e xternal multiple muscle layers (myocardial sleeve), such sleeve is absent in veins that have no connection with the left atrium irrespective of the type of the defect. In patients with total anomalous pulmonary venous drainage, the structure of left atrium was heterogeneous featuring either the presence or absence of inner angiomural lining in this atrium. The structural peculiarities are important for insight into etiology of the development of postoperative pulmonary venous obstruction in patients with total anomalous pulmonary venous drainage.