Use of Molecular Imaging Markers of Glycolysis, Hypoxia and Proliferation (18F-FDG, 64Cu-ATSM and 18F-FLT) in a Dog with Fibrosarcoma: The Importance of Individualized Treatment Planning and Monitoring

Glycolysis, hypoxia, and proliferation are important factors in the tumor microenvironment contributing to treatment-resistant aggressiveness. Imaging these factors using combined functional positron emission tomography and computed tomography can potentially guide diagnosis and management of cancer...

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Published inDiagnostics (Basel) Vol. 5; no. 3; pp. 372 - 382
Main Authors Zornhagen, Kamilla, Clausen, Malene, Hansen, Anders, Law, Ian, McEvoy, Fintan, Engelholm, Svend, Kjær, Andreas, Kristensen, Annemarie
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 01.09.2015
MDPI
Subjects
18F-FDG
18F-FLT
64Cu-ATSM
Cancer
canine fibrosarcoma
Case Report
Dogs
Hypoxia
individualized response monitoring
PET/CT
positron emission tomography
Tomography
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Summary:Glycolysis, hypoxia, and proliferation are important factors in the tumor microenvironment contributing to treatment-resistant aggressiveness. Imaging these factors using combined functional positron emission tomography and computed tomography can potentially guide diagnosis and management of cancer patients. A dog with fibrosarcoma was imaged using 18F-FDG, 64Cu-ATSM, and 18F-FLT before, during, and after 10 fractions of 4.5 Gy radiotherapy. Uptake of all tracers decreased during treatment. Fluctuations in 18F-FDG and 18F-FLT PET uptakes and a heterogeneous spatial distribution of the three tracers were seen. Tracer distributions partially overlapped. It appears that each tracer provides distinct information about tumor heterogeneity and treatment response.
ISSN:2075-4418
2075-4418
DOI:10.3390/diagnostics5030372