Bloodstream infections and carbapenem-resistant Enterobacteriaceae in South Korea

• Published in: The Lancet infectious diseases Vol. 19; no. 9; pp. 931 - 932
• Main Authors: Yoon, Eun-Jeong, Kim, Dokyun, Jeong, Seok Hoon
• Format: Journal Article
• Language: English
• Published: United States Elsevier Ltd 01.09.2019; Elsevier Limited
• Subjects: Antimicrobial agents; Cephalosporins; CRE bacteria; Disease control; Drug resistance; E coli; Infectious diseases; Mortality; Risk analysis; Risk factors; β Lactamase; South Korea
• ISSN: 1473-3099; 1474-4457
• DOI: 10.1016/S1473-3099(19)30431-1

Notably, resistance of E coli isolates to third-generation and fourth-generation cephalosporins was high (35·1%, 524 of 1492 isolates), the associated blaCTX-M extended-spectrum beta-lactamase genes were widespread (31·0%, 463 of 1492 isolates), and the high proportion of inadequate empirical antimicrobial therapy (52·7%, 276 of 524 isolates) and 30-day mortality (12·8%, 67 of 524 patients) were affected by the third-generation and fourth-generation cephalosporin resistance. The hypervirulent K1 (13·5%, 78 of 579 isolates), which was associated with liver abscess, and K2 (20·9%, 121 of 579 isolates) were the predominant capsular types.3 The 30-day mortality rate of patients with BSIs because of K pneumoniae was 16·9% (98 of 579 patients), and the capsular type wzi50, which is associated with neither K1 nor K2, was a risk factor. E-JY, DK, and SHJ report a grant from Korea Centers for Disease Control and Prevention (KCDC2017E4400102#), during the conduct of the study.