The Unique Fiber Anatomy of Middle Temporal Gyrus Default Mode Connectivity

• Published in: Operative neurosurgery (Hagerstown, Md.) Vol. 21; no. 1; pp. E8 - E14
• Main Authors: Briggs, Robert G, Tanglay, Onur, Dadario, Nicholas B, Young, Isabella M, Fonseka, R Dineth, Hormovas, Jorge, Dhanaraj, Vukshitha, Lin, Yueh-Hsin, Kim, Sihyong J, Bouvette, Adam, Chakraborty, Arpan R, Milligan, Ty M, Abraham, Carol J, Anderson, Christopher D, O’Donoghue, Daniel L, Sughrue, Michael E
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 01.07.2021; Wolters Kluwer Health, Inc
• Subjects: Adult; Brain; Brain surgery; Cognition & reasoning; Connectome; Dissection; Humans; Language; Nerve Net; Neural Pathways - diagnostic imaging; Neurosurgery; Semantics; Speech; Surgical Anatomy and Technique; Temporal Lobe - diagnostic imaging; White Matter - diagnostic imaging; MTG; DSI; Middle temporal gyrus; Anatomy; White matter; Tractography
• ISSN: 2332-4252; 2332-4260
• DOI: 10.1093/ons/opab109

Abstract BACKGROUND The middle temporal gyrus (MTG) is understood to play a role in language-related tasks such as lexical comprehension and semantic cognition. However, a more specific understanding of its key white matter connections could promote the preservation of these functions during neurosurgery. OBJECTIVE To provide a detailed description of the underlying white matter tracts associated with the MTG to improve semantic preservation during neurosurgery. METHODS Tractography was performed using diffusion imaging obtained from 10 healthy adults from the Human Connectome Project. All tracts were mapped between cerebral hemispheres with a subsequent laterality index calculated based on resultant tract volumes. Ten postmortem dissections were performed for ex vivo validation of the tractography based on qualitative visual agreement. RESULTS We identified 2 major white matter bundles leaving the MTG: the inferior longitudinal fasciculus and superior longitudinal fasciculus. In addition to long association fibers, a unique linear sequence of U-shaped fibers was identified, possibly representing a form of visual semantic transfer down the temporal lobe. CONCLUSION We elucidate the underlying fiber-bundle anatomy of the MTG, an area highly involved in the brain's language network. Improved understanding of the unique, underlying white matter connections in and around this area may augment our overall understanding of language processing as well as the involvement of higher order cerebral networks like the default mode network in these functions.