Primary cutaneous diffuse large B-cell lymphoma, leg type and secondary cutaneous involvement by testicular B-cell lymphoma share identical clinicopathological and immunophenotypical features

• Published in: Journal of the American Academy of Dermatology Vol. 66; no. 4; pp. 650 - 654
• Main Authors: Muniesa, Cristina, MD, Pujol, Ramon M., MD, Estrach, M. Teresa, MD, Gallardo, Fernando, MD, García-Muret, M. Pilar, MD, Climent, Josefina, MD, Salar, Antonio, MD, Servitje, Octavio, MD
• Format: Journal Article
• Language: English
• Published: New York, NY Mosby, Inc 01.04.2012; Elsevier
• Subjects: Aged; Biological and medical sciences; Dermatology; extracutaneous involvement; extracutaneous spread; Hematologic and hematopoietic diseases; Humans; Immunophenotyping; Leg; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Lymphoma, B-Cell - genetics; Lymphoma, B-Cell - immunology; Lymphoma, B-Cell - pathology; Lymphoma, Large B-Cell, Diffuse - genetics; Lymphoma, Large B-Cell, Diffuse - immunology; Lymphoma, Large B-Cell, Diffuse - pathology; Male; Medical sciences; primary cutaneous diffuse large B-cell lymphoma leg type; secondary cutaneous involvement; Skin Neoplasms - genetics; Skin Neoplasms - immunology; Skin Neoplasms - pathology; testicular involvement; testicular lymphoma; Testicular Neoplasms - secondary; extracutaneous spread; testicular lymphoma; computed tomography; primary cutaneous diffuse large B-cell lymphoma leg type; primary cutaneous diffuse large B-cell lymphoma; CNS; central nervous system; secondary cutaneous involvement; CT; testicular involvement; extracutaneous involvement; EBV; PCDLBCL; Epstein-Barr virus; Skin disease; Cutaneous hematologic disease; Dermatology; Cutaneous B cell lymphoma; Lymphoproliferative syndrome; Diffuse large B cell lymphoma; Malignant hemopathy; Non Hodgkin lymphoma; Testicle; Cancer; Leg
• ISSN: 0190-9622; 1097-6787
• DOI: 10.1016/j.jaad.2011.03.031

Background Primary cutaneous diffuse large B-cell lymphoma (PCDLBCL), leg type can eventually disseminate to extracutaneous sites including testes. In addition, patients with testicular lymphoma can develop specific skin involvement. Objective We sought to describe similarities between PCDLBCL, leg type and testicular B-cell lymphoma affecting the skin. Methods We report two cases with typical clinicopathological and immunophenotypical features of leg type lymphoma occurring simultaneously with a testicular B-cell lymphoma. We also report an additional case of PCDLBCL, leg type with secondary testicular involvement. Results All cases presented with typical red tumors exclusively located on the legs. Histologically, all cases showed a diffuse nonepidermotropic infiltrate composed of large blastic cells mainly centroblastic type. Phenotype showed strong positivity for Bcl-2, MUM-1, and FOXP1. Epstein-Barr virus stains and CD30 were negative in the 3 cases. In all cases the testicular infiltration showed the same pathological and phenotypical changes to those observed in the skin. Limitations This was a retrospective case series study. Conclusion Skin involvement by testicular B-cell lymphomas and PCDLBCL, leg type are indistinguishable on the basis of pathologic and immunophenotypical features, therefore specific investigation and clinic correlation are needed.