Effect of the consumption of hesperidin in orange juice on the transcriptomic profile of subjects with elevated blood pressure and stage 1 hypertension: A randomized controlled trial (CITRUS study)

• Published in: Clinical nutrition (Edinburgh, Scotland) Vol. 40; no. 12; pp. 5812 - 5822
• Main Authors: Pla-Pagà, Laura, Valls, Rosa M., Pedret, Anna, Calderón-Pérez, Lorena, Llauradó, Elisabet, Companys, Judit, Domenech-Coca, Cristina, Canela, Nuria, del Bas, Josep M., Caimari, Antoni, Puiggròs, Francesc, MI, Covas, Arola, Lluís, Solà, Rosa
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.12.2021
• Subjects: 3-Hydroxysteroid Dehydrogenases - metabolism; Adult; Blood Pressure - genetics; Citrus; Citrus sinensis; clinical nutrition; Double-Blind Method; Down-Regulation; Female; Fruit and Vegetable Juices; Gene Expression - drug effects; genes; Hesperidin; Hesperidin - administration & dosage; Hesperidin - pharmacology; Humans; hypertension; Hypertension - genetics; Hypertensive subjects; inflammation; insulin resistance; Leukocytes, Mononuclear - metabolism; Male; mechanism of action; Middle Aged; Orange juice; PBMCs; Plasma; randomized clinical trials; Selenium-Binding Proteins - metabolism; systolic blood pressure; Transcriptome - drug effects; Transcriptomic analysis; transcriptomics; SBP; Plasma; CD; EOJ; LncRNA; Transcriptomic analysis; PBMCs; CVD; Hypertensive subjects; DBP; Orange juice; IPA; OJ; Hesperidin; CVDR; CVDRFs

Hesperidin exerts cardiovascular beneficial effects, but its mechanisms of action remain undefined. In a previous study we demonstrated that a single dose and a 12-week treatment of hesperidin decreased systolic blood pressure. The aim of this study was to ascertain the action mechanisms of hesperid...