Radiofrequency Ablation Combined with Transarterial Chemoembolization for Liver Metastases from Gastrointestinal Cancers

• Published in: Journal of Huazhong University of Science and Technology. Medical sciences Vol. 36; no. 2; pp. 200 - 204
• Main Author: 阚雪锋 王勇 林国成 夏向文 熊斌 周国锋 梁惠民 冯敢生 郑传胜
• Format: Journal Article
• Language: English
• Published: Wuhan Huazhong University of Science and Technology 01.04.2016; Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022,China%Department of Radiology, Yichang Second People's Hospital, Yichang 443000, China
• Subjects: Ablation Techniques - adverse effects; Adult; Aged; Aged, 80 and over; Chemoembolization, Therapeutic - adverse effects; Female; Gastrointestinal Neoplasms - pathology; Gastrointestinal Neoplasms - therapy; Humans; Liver Neoplasms - secondary; Liver Neoplasms - therapy; Male; Medicine; Medicine & Public Health; Middle Aged; Pulsed Radiofrequency Treatment - adverse effects; RFA; Survival Analysis; 化疗; 射频消融; 栓塞; 肝动脉; 肝细胞癌; 肠肿瘤; 胃肠道; overall survival; radiofrequency ablation; transarterial chemoembolization; gastrointestinal cancer; liver metastases
• ISSN: 1672-0733; 1993-1352; 1993-1352
• DOI: 10.1007/s11596-016-1566-y

Transarterial chemoembolization（TACE） combined with radiofrequency ablation（RFA） has been reported to be effective for local control of different-sized hepatocellular carcinomas. However, it is unclear if these benefits could also be applicable to different-sized liver metastases from gastrointestinal cancers. The aim of this study was to evaluate the outcomes of TACE combined with RFA for liver metastases from gastrointestinal cancers. In this study, we retrospectively analyzed clinical data of 19 consecutive patients who had a total of 26 liver metastatic lesions from gastrointestinal cancers and underwent RFA followed by first-time TACE treatment. The tumor recurrence, overall survival rate and procedure-related complications were evaluated. Moreover, patients＇ demographics and tumor characteristics were analyzed to determine their impact on the outcomes. The technical success of TACE plus RFA was achieved with 2 major procedure-related complications found. The mean follow-up was 21.3 months. The total 1-, 2-, and 3-year survival rate was 89.4%, 52.6%, and 35.1%, respectively. It was found that the tumor size and the ratio of enhancement area were significant factors that influenced the overall survival. In conclusion, patients with gastrointestinal cancer-derived liver metastatic lesions of smaller size and larger enhancement area are considered appropriate candidates for TACE plus RFA.