Invasive Pneumococcal Disease Characterization in Adults and Subgroups aged < 60 years and ≥ 60 years in Bogota, Colombia

• Published in: IJID regions Vol. 3; pp. 293 - 299
• Main Authors: Castro, Aura Lucia Leal, Camacho-Moreno, Germán, Montañez-Ayala, Anita, Varón-Vega, Fabio, Alvarez-Rodríguez, José Camilo, Valderrama-Beltrán, Sandra, Ariza, Beatriz Elena, Pancha, Oscar, Santana, Ana Yadira, Flórez, Nella Sánchez, Reyes, Patricia, Ruiz, Jaime, Beltran, Claudia, Prieto, Emilia, Rojas, Monica, Urrego-Reyes, Juan, Parellada, Cintia Irene
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01.06.2022; Elsevier
• Subjects: healthcare resource utilization, antimicrobial resistance; Original Report; Streptococcus pneumoniae, pneumococcal infection, adult, older adult, mortality; healthcare resource utilization, antimicrobial resistance; Streptococcus pneumoniae, pneumococcal infection, adult, older adult, mortality
• ISSN: 2772-7076; 2772-7076
• DOI: 10.1016/j.ijregi.2022.04.007

•The clinical burden of IPD is high in the elderly and adults with comorbidities•IPD placed a high burden on healthcare resources in the adult population•The most common types causing IPD in adults were similar to those found in children•Policy makers should consider pneumococcal vaccination for populations at risk There is scarce information on the burden of invasive pneumococcal disease (IPD) among adults in low- and middle-income countries. This study aimed to describe the clinical outcomes and microbiological characteristics associated with IPD in adults and subgroups aged 18-59 years and ≥60 years in Colombia A retrospective chart review study was conducted in five institutions of Bogotá from January 2011 to December 2017. Analyses were carried out for overall population and stratified by age group (18-59; ≥ 60 years) There were 169 IPD cases; median age was 58 years, 51.5% were male, and 80.5% had at least one comorbidity. Bacteremic pneumonia was the most common presentation (63.9%). The median length of hospital stay was 12 days with high healthcare resource utilization (HCRU): 58.6% required ICU and 53.3% inotropic support. Overall case-fatality rate (CFR) was 41.4%. Clinical outcomes were worse in patients ≥60 years old with significantly higher CFR and HCRU (ICU admission, mechanical ventilation, and inotropic support) compared to those aged 18-59 years. The most frequent serotypes were 3, 6 A/C, 14, and 19A. The sensitivity to penicillin in meningitis and non-meningitis isolates were 75% and 89.1% respectively IPD was associated with a substantial burden in adults and worse clinical outcomes and HCRU in older adults in Colombia. Surveillance data combined with clinical outcomes have the potential to inform age-based pneumococcal vaccination policies.