Gallbladder cancer epidemiology, pathogenesis and molecular genetics: Recent update

Gallbladder cancer is a malignancy of biliary tract which is infrequent in developed countries but common in some specific geographical regions of developing countries. Late diagnosis and deprived prognosis are major problems for treatment of gallbladder carcinoma. The dramatic associations of this...

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Published inWorld journal of gastroenterology : WJG Vol. 23; no. 22; pp. 3978 - 3998
Main Authors Sharma, Aarti, Sharma, Kiran Lata, Gupta, Annapurna, Yadav, Alka, Kumar, Ashok
Format Journal Article
LanguageEnglish
Published United States Baishideng Publishing Group Inc 14.06.2017
Subjects
Biomarkers, Tumor - genetics
DNA Methylation
Epigenesis, Genetic
Gallbladder Neoplasms - epidemiology
Gallbladder Neoplasms - genetics
Gallbladder Neoplasms - pathology
Gene Expression Regulation, Neoplastic
Genetic Predisposition to Disease
Humans
Loss of Heterozygosity
Microsatellite Instability
Molecular Epidemiology
Mutation
Phenotype
Review
Risk Factors
Molecular genetics
Pathogenesis
Epidemiology
Gallbladder cancer
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Summary:Gallbladder cancer is a malignancy of biliary tract which is infrequent in developed countries but common in some specific geographical regions of developing countries. Late diagnosis and deprived prognosis are major problems for treatment of gallbladder carcinoma. The dramatic associations of this orphan cancer with various genetic and environmental factors are responsible for its poorly defined pathogenesis. An understanding to the relationship between epidemiology, molecular genetics and pathogenesis of gallbladder cancer can add new insights to its undetermined pathophysiology. Present review article provides a recent update regarding epidemiology, pathogenesis, and molecular genetics of gallbladder cancer. We systematically reviewed published literature on gallbladder cancer from online search engine Pub Med(http://www.ncbi.nlm.nih.gov/pubmed). Various keywords used for retrieval of articles were Gallbladder, cancer Epidemiology, molecular genetics and bullion operators like AND, OR, NOT. Cross references were manually searched from various online search engines(http://www.ncbi.nlm.nih.gov/pubmed,https://scholar.google.co.in/, http://www.medline.com/home.jsp). Most of the articles published from 1982 to 2015 in peer reviewed journals have been included in this review.
Bibliography:Aarti Sharma;Kiran Lata Sharma;Annapurna Gupta;Alka Yadav;Ashok Kumar;Department of Surgical Gastroenterology, Sanjay Gandhi Post Graduate Institute of Medical Sciences;Department of Biochemistry and Medical Genetics, John Buhler Research Centre, University of Manitoba
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Author contributions: Sharma A, Sharma KL and Kumar A have written the manuscript; Sharma A, Sharma KL and Gupta A has contributed in literature search; Sharma A, Sharma KL, Gupta A and Yadav A have contributed in designing tables as well as referencing; Kumar A is senior Corresponding author; Sharma KL is co-corresponding author; all the authors have approved the final version of the manuscript.
Telephone: +91-522-2494423 Fax: +91-522-2668017
Correspondence to: Dr. Ashok Kumar, Professor, Department of Surgical Gastroenterology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Raebareli Road, Lucknow 226014, India. akgupta@sgpgi.ac.in
ISSN:1007-9327
2219-2840
2219-2840
DOI:10.3748/wjg.v23.i22.3978