Nonalcoholic fatty liver disease:Updates in noninvasive diagnosis and correlation with cardiovascular disease
Nonalcoholic fatty liver disease(NAFLD)refers to the accumulation of fat(mainly triglycerides)within hepatocytes.Approximately 20%-30%of adults in the general population in developed countries have NAFLD;this trend is increasing because of the pandemicity of obesity and diabetes,and is becoming a se...
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Published in | World journal of gastroenterology : WJG Vol. 20; no. 24; pp. 7718 - 7729 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
Baishideng Publishing Group Inc
28.06.2014
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Subjects | |
Online Access | Get full text |
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Summary: | Nonalcoholic fatty liver disease(NAFLD)refers to the accumulation of fat(mainly triglycerides)within hepatocytes.Approximately 20%-30%of adults in the general population in developed countries have NAFLD;this trend is increasing because of the pandemicity of obesity and diabetes,and is becoming a serious public health burden.Twenty percent of individuals with NAFLD develop chronic hepatic inflammation[nonalcoholic steatohepatitis(NASH)],which can be associated with the development of cirrhosis,portal hypertension,and hepatocellular carcinoma in a minority of patients.And thus,the detection and diagnosis of NAFLD is important for general practitioners.Liver biopsy is the gold standard for diagnosing NAFLD and confirming the presence of NASH.However,the invasiveness of this procedure limits its application to screening the general population or patients with contraindications for liver biopsy.The development of noninvasive diagnostic methods for NAFLD is of paramount importance.This review focuses on the updates of noninvasive diagnosis of NAFLD.Besides,we review clinical evidence supporting a strong association between NAFLD and the risk of cardiovascular disease because of the cross link between these two disorders. |
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Bibliography: | Kuang-Chun Hu;Horng-Yuan Wang;Sung-Chen Liu;Chuan-Chuan Liu;Chung-Lieh Hung;Ming-Jong Bair;Chun-Jen Liu;Ming-Shiang Wu;Shou-Chuan Shih;Mackay Medical College;Division of Gastroenterology,Department of Internal Medicine,Health Evaluation Center,Mackay Memorial Hospital;Graduate Institute of Clinical Medicine,National Taiwan University College of Medicine;Division of Endocrine,Department of Internal Medicine,DM Center,Mackay Memorial Hospital;Division of Cardiology,Department of Internal Medicine,Mackay Memorial Hospital;Gastroenterology Division,Department of Internal Medicine,Mackay Memorial Hospital,Taitung Branch ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 Correspondence to: Dr. Shou-Chuan Shih, Division of Gastroenterology, Department of Internal Medicine, Health Evaluation Center, Mackay Memorial Hospital, No.92, Sec. 2, Chung-Shan North Road, Taipei 10449, Taiwan. shihshou@gmail.com Telephone: +886-2-25433535 Fax: +886-2-25433642 Author contributions: Shih SC and Liu CJ contributed equally to this work; Wang HY, Liu SC, Liu CC, Bair MJ and Wu MS designed the research and article review; Hung CL designed the cardiovascular disease research and article review; and Hu KC analyzed the article and wrote the paper. |
ISSN: | 1007-9327 2219-2840 |
DOI: | 10.3748/wjg.v20.i24.7718 |