Low-FODMAP diet reduces irritable bowel symptoms in patients with inflammatory bowel disease

• Published in: World journal of gastroenterology : WJG Vol. 23; no. 18; pp. 3356 - 3366
• Main Authors: Pedersen, Natalia, Ankersen, Dorit Vedel, Felding, Maria, Wachmann, Henrik, Végh, Zsuzsanna, Molzen, Line, Burisch, Johan, Andersen, Jens Rikardt, Munkholm, Pia
• Format: Journal Article
• Language: English
• Published: United States Baishideng Publishing Group Inc 14.05.2017
• Subjects: Adult; Aged; C-Reactive Protein - metabolism; Diet; Disaccharides - chemistry; Female; Fermentation; Humans; Inflammatory Bowel Diseases - diagnosis; Inflammatory Bowel Diseases - therapy; Internet; Irritable Bowel Syndrome - diagnosis; Irritable Bowel Syndrome - therapy; Male; Middle Aged; Monosaccharides - chemistry; Oligosaccharides - chemistry; Patient Compliance; Prospective Studies; Quality of Life; Randomized Controlled Trial; Remission Induction; Young Adult; Inflammatory bowel disease; Web-based management; Irritable bowel syndrome; Low-FODMAP diet
• ISSN: 1007-9327; 2219-2840
• DOI: 10.3748/wjg.v23.i18.3356

AIM To investigate the effect of a low-FODMAP diet on irritable bowel syndrome(IBS)-like symptoms in patients with inflammatory bowel disease(IBD).METHODS This was a randomised controlled open-label trial of patients with IBD in remission or with mild-to-moderate disease and coexisting IBS-like symptoms(Rome III) randomly assigned to a Low-FODMAP diet(LFD) or a normal diet(ND) for 6 wk between June 2012 andDecember 2013. Patients completed the IBS symptom severity system(IBS-SSS) and short IBD quality of life questionnaire(SIBDQ) at weeks 0 and 6. The primary end-point was response rates(at least 50-point reduction) in IBS-SSS at week 6 between groups; secondary end-point was the impact on quality of life. RESULTS Eighty-nine patients, 67(75%) women, median age 40, range 20-70 years were randomised: 44 to LFD group and 45 to ND, from which 78 patients completed the study period and were included in the final analysis(37 LFD and 41 ND). There was a significantly larger proportion of responders in the LFD group(n = 30, 81%) than in the ND group(n = 19, 46%);(OR = 5.30; 95%CI: 1.81-15.55, P < 0.01). At week 6, the LFD group showed a significantly lower median IBSSSS(median 115; inter-quartile range [IQR] 33-169) than ND group(median 170, IQR 91-288), P = 0.02. Furthermore, the LFD group had a significantly greater increase in SIBDQ(median 60, IQR 51-65) than the ND group(median 50, IQR 39-60), P < 0.01.CONCLUSION In a prospective study, a low-FODMAP diet reduced IBS-like symptoms and increased quality of life in patients with IBD in remission.