Chemical structures of angiotensins formed by incubating plasma with the kidney and the corpuscles of Stannius in the chum salmon, Oncorhynchus keta

• Published in: General and comparative endocrinology Vol. 51; no. 2; pp. 219 - 227
• Main Authors: Takemoto, Yumi, Nakajima, Terumi, Hasegawa, Yukio, Watanabe, Takushi X., Sokabe, Hirofumi, Kumagae, Shin-ichiro, Sakakibara, Shumpei
• Format: Journal Article
• Language: English
• Published: San Diego, CA Elsevier Inc 01.01.1983; Elsevier
• Subjects: Amino Acid Sequence; Angiotensins - administration & dosage; Angiotensins - isolation & purification; Animals; Biological and medical sciences; Blood Pressure; Brackish; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Female; Freshwater; Fundamental and applied biological sciences. Psychology; Hormones and neuropeptides. Regulation; Hypothalamus. Hypophysis. Epiphysis. Urophysis; Kidney - analysis; Kidney - metabolism; Marine; Oncorhynchus keta; Organ Specificity; Peptides - analysis; Plasma - physiology; Rats; Rats, Inbred Strains; Salmon - metabolism; Vertebrates: endocrinology; Vertebrata; Pisces; Angiotensin; Stannius corpuscle; Peptide hormone; Chemical structure; Biosynthesis; Comparative study; Kidney
• ISSN: 0016-6480; 1095-6840
• DOI: 10.1016/0016-6480(83)90075-8

The chemical structures of salmon angiotensins produced by incubating tissue extract of the kidney or the corpuscles of Stannius (CS) with homologous plasma are proposed, Two angiotensins, [Asp 1, Val 5, Asn 9] and [Asn 1, Val 5, Asn 9] angiotensin I, were proposed from both kidney and CS incubations by amino acid analysis and the fluorescent peptide-mapping techniques. CS angiotensis were not organ specific, because these two angiotensins were produced by both kidney and CS incubations in a ratio of 1:2 under the same conditions. Whether [Asp 1, Val 5, Asn 9] angiotensin I is a naturally occurring form remains to be clarified; however, [Asn 1, Val 5, Asn 9] angiotensin I may be the major form of angiotensin formed from plasma by salmon kidney and CS.