Autophagy and kidney aging

• Published in: Progress in biophysics and molecular biology Vol. 179; pp. 10 - 15
• Main Authors: Minami, Satoshi, Yamamoto, Takeshi, Yamamoto-Imoto, Hitomi, Isaka, Yoshitaka, Hamasaki, Maho
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.05.2023
• Subjects: Aging; Autophagosomes - metabolism; Autophagy; Chronic kidney disease; Humans; Kidney; Kidney aging; Lysosome; Organelles; Kidney aging; Rubicon; Bnip3; Lysosome; ROS; SASPs; Foxo3a; Chronic kidney disease; Autophagy; CKD; AKI

Autophagy is a highly conserved intracellular degradation system in eukaryotes that maintains cellular and tissue homeostasis. Upon autophagy induction, cytoplasmic components are engulfed by a double-membrane organelle called the autophagosome that fuses with a lysosome to degrade its contents. In...