Autophagy and kidney aging

Autophagy is a highly conserved intracellular degradation system in eukaryotes that maintains cellular and tissue homeostasis. Upon autophagy induction, cytoplasmic components are engulfed by a double-membrane organelle called the autophagosome that fuses with a lysosome to degrade its contents. In...

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Published inProgress in biophysics and molecular biology Vol. 179; pp. 10 - 15
Main Authors Minami, Satoshi, Yamamoto, Takeshi, Yamamoto-Imoto, Hitomi, Isaka, Yoshitaka, Hamasaki, Maho
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.05.2023
Subjects
Aging
Autophagosomes - metabolism
Autophagy
Chronic kidney disease
Humans
Kidney
Kidney aging
Lysosome
Organelles
Kidney aging
Rubicon
Bnip3
Lysosome
ROS
SASPs
Foxo3a
Chronic kidney disease
Autophagy
CKD
AKI
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Summary:Autophagy is a highly conserved intracellular degradation system in eukaryotes that maintains cellular and tissue homeostasis. Upon autophagy induction, cytoplasmic components are engulfed by a double-membrane organelle called the autophagosome that fuses with a lysosome to degrade its contents. In recent years, it has become clear that autophagy becomes dysregulated with aging, which leads to age-related diseases. Kidney function is particularly prone to age-related decline, and aging is the most significant risk factor for chronic kidney disease. This review first discuss the relationship between autophagy and kidney aging. Second, we describe how age-related dysregulation of autophagy occurs. Finally, we discuss the potential of autophagy-targeting drugs to ameliorate human kidney aging and the approaches necessary to discover such agents.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:0079-6107
1873-1732
1873-1732
DOI:10.1016/j.pbiomolbio.2023.02.005