Human genes involved in hepatitis B virus infection

Persistent hepatitis B virus(HBV)infection is a significant public health problem because it is a major cause of chronic liver disease,cirrhosis,and hepatocellular carcinoma(HCC).Roughly one-third of the world population has been infected with HBV and there are about350 million(5%-6%)persistent carr...

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Published inWorld journal of gastroenterology : WJG Vol. 20; no. 24; pp. 7696 - 7706
Main Author Zeng, Zheng
Format Journal Article
LanguageEnglish
Published United States Baishideng Publishing Group Inc 28.06.2014
Subjects
carcinoma
Epidemi
Genetic Markers
Genetic Predisposition to Disease
Hepatitis
Hepatitis B - genetics
Hepatitis B - virology
Hepatitis B virus - pathogenicity
Hepatocellular
Host-Pathogen Interactions - genetics
Humans
Phenotype
Prognosis
Risk Factors
Topic Highlight
virus
Outcome
Genetic
Hepatocellular carcinoma
Clearance
Hepatitis B virus
Epidemiology
Persistance
Natural history
Polymorphism
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Summary:Persistent hepatitis B virus(HBV)infection is a significant public health problem because it is a major cause of chronic liver disease,cirrhosis,and hepatocellular carcinoma(HCC).Roughly one-third of the world population has been infected with HBV and there are about350 million(5%-6%)persistent carriers.HBV causes80%of all liver cancer cases and is the second most important carcinogen,after smoking tobacco.There is an approximate 90%risk of becoming a persistent carrier following perinatal infection in infants born to e antigen positive carrier mothers and a 30%risk in pre-school children.Only 5%-10%of adults become persistent carriers following infection.Of individuals persistently infected with HBV,10%-30%will develop liver cirrhosis and HCC.These highly variable outcomes in both clearance rates and disease outcomes in persistently infected individuals cannot be fully explained by differences in immunological,viral or environmental factors.Thus,differences in host genetic factors may affect the natural history of hepatitis B.
Bibliography:Zheng Zeng;Department of Infectious Diseases,Peking University First Hospital
Correspondence to: Zheng Zeng, Professor, Department of Infectious Diseases, Peking University First Hospital, No. 8, Xishiku Street, Xicheng District, Beijing 100034, China. zeng@bjmu.edu.cn
Author contributions: Zeng Z designed and wrote the manuscript.
Telephone: +86-10-83572370 Fax: +86-10-66551799
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.v20.i24.7696