Fluorescent glycoconjugates and their applications
Glycoconjugates and their applications as lectin ligands in biology have been thoroughly investigated in the past decades. Meanwhile, the intrinsic properties of such multivalent molecules were limited essentially to their ability to bind to their receptors with high selectivity and/or avidity. The...
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| Published in | Chemical Society reviews Vol. 49; no. 2; pp. 593 - 641 |
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| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Royal Society of Chemistry
27.01.2020
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| Subjects | |
| Online Access | Get full text |
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| Summary: | Glycoconjugates and their applications as lectin ligands in biology have been thoroughly investigated in the past decades. Meanwhile, the intrinsic properties of such multivalent molecules were limited essentially to their ability to bind to their receptors with high selectivity and/or avidity. The present review will focus on multivalent glycoconjugates displaying an additional capability such as fluorescence properties not only for applications toward imaging of cancer cells and detection of proteins or pathogens but also for drug delivery systems toward targeted cancer therapy. This review is a collection of research articles discussed in the context of the structural features of fluorescent glycoconjugates organized according to their fluorescent core scaffold and with their representative applications.
Fluorescent glycoconjugates are discussed for their applications in biology
in vitro
, in cell assays and in animal models. Advantages and limitations are presented for each design using a fluorescent core conjugated with glycosides, or
vice versa
. |
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| Bibliography: | Xiao-Peng He received his BSc in Applied Chemistry (2006) and PhD in Pharmaceutical Engineering (2011) from ECUST. He completed a co-tutored doctoral program at ENS Cachan (France) from July 2008 to February 2009. Then he carried out his postdoctoral research with Prof. Kaixian Chen (SIMM, CAS) at ECUST from 2011 to 2013. He is now a professor at the Feringa Nobel Prize Scientists Joint Research Center, School of Chemistry and Molecular Engineering, ECUST, where his research interests span chemical glycobiology to fluorescent molecular probes and functional materials for disease diagnostics and theranostics. Kai-Cheng Yan received his BSc in Industrial Engineering (2017) from SHOU and he is currently pursuing his master's degree in Pharmaceutical Engineering with Prof. Xiao-Peng He at the School of Chemistry and Molecular Engineering, ECUST. Guo-Rong Chen received her BSc in Organic Chemical Engineering (1975) from ECUST. She conducted her research at the Glycochemistry Laboratory of the University of Lyon from 1989 to 1991. She revisited the lab in 1996, 1998, and 2002. Then she spent two years at Shanghai Institute of Materia Medica (CAS) as a visiting scholar. She was appointed as a professor at ECUST in 2001, and her research interests involve glycochemistry, medicinal glycochemistry, chemical glycobiology and green fine chemicals. Baptiste Thomas received his PhD in bioorganic chemistry in 2014 (University of Grenoble, France - Prof. Olivier Renaudet) studying the design of hetero-glycoclusters as synthetic vaccines. He then moved to the group of Prof. Sabine Flitsch at the University of Manchester (UK) for the development of a label-free array platform for the discovery of glycan binding proteins. In 2017, he joined the group of Dr Sébastien Vidal at the University of Lyon (France) to synthesize the trisaccharide repeating unit of the O-Antigen of Escherichia coli Type O26. He is currently a project manager at Smartox Biotechnology (Grenoble) developing the synthesis of peptides from animal venoms. Xi-Le Hu received his BSc in Applied Chemistry (2012) from SIT and PhD in Pharmaceutical Engineering and Technology (2017) from ECUST. He is currently a postdoctoral research fellow with Prof. He Tian at ECUST, where his research interest focuses on new non-antibiotic materials for superbugs. Marion Donnier-Maréchal received her PhD in medicinal chemistry in 2013 (University of Lille, France - Prof. Patricia Melnyk and Dr Pascal Carato) studying the design and synthesis of neuroprotective agents for the treatment of neurodegenerative diseases. She then moved to the group of Dr Sébastien Vidal at the University of Lyon (France) for the design of fluorescent glycoclusters; she then worked with Prof. Julien Leclaire to study dynamic combinatorial chemistry. In 2017, she joined the group of Prof. Christopher Hunter at the University of Cambridge (England) to design and synthesize fluorescent probes for the detection of amyloid proteins in neurodegenerative diseases. Sébastien Vidal received his PhD in organic chemistry in 2000 (University of Montpellier, France - Prof. Jean-Louis Montero and Prof. Alain Morère) on the synthesis of mannose 6-phosphate analogues. He then moved to UCLA with Sir J. Fraser Stoddart (Nobel Prize in Chemistry 2016) to study glycodendrimers. In 2003, he joined NREL (Golden, Colorado) with Prof Joseph Bozell and studied the combination of organometallic and carbohydrate chemistries. He obtained a CNRS position at the University of Lyon in 2004 and started his own projects on carbohydrate chemistry and applications in biology. He has now joined the Institut de Chimie des Substances Naturelles. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23 |
| ISSN: | 0306-0012 1460-4744 1460-4744 |
| DOI: | 10.1039/c8cs00118a |