DEVELOPMENTAL CHANGE OF Ca2+-ATPASE ACTIVITY ON PLASMA MEMBRANE OF RAT PANCREAS DURING PERINATAL PERIOD

• Published in: ACTA HISTOCHEMICA ET CYTOCHEMICA Vol. 23; no. 6; pp. 805 - 816
• Main Authors: LEE, JUNG NAM, ARAKI, NOBUKAZU, TAKASHIMA, YOICHIRO
• Format: Journal Article
• Language: English
• Published: Kyoto JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY 01.01.1990; Japan Society of Histochemistry and Cytochemistry; Japan Science and Technology Agency
• Subjects: Analytical, structural and metabolic biochemistry; Biological and medical sciences; Enzymes and enzyme inhibitors; Fundamental and applied biological sciences. Psychology; Ca-ATPase; Vertebrata; Regulation(control); Mammalia; Enzymatic activity; Rat; Enzyme; Rodentia; Plasma membrane; Perinatal; Pancreas
• ISSN: 0044-5991; 1347-5800
• DOI: 10.1267/ahc.23.805

Cat+-ATPase activity in rat pancreatic exocrine cells and endocrine cells during perinatal development was cytochemically examined at the electron microscopic level. The intense enzyme activity on the plasma membrane of endocrine cells was observed from the beginning of differentiation of endocrine cells, as well as in adult rats. However, no activity was seen on the plasma membrane of exocrine cells in prenatal rats. Ca2+-ATPase activity on the basolateral plasma membrane of exocrine cells appeared after birth, whereas pancreatic acini and zymogen granules were fully developed during the late embryonic stage. It seemed that the appearance of Ca2+-ATPase activity on the plasma membrane corresponded to the beginning of exocrine secretory function. These results suggest that Ca2+-ATPase activity on plasma membrane of exocrine cells may be deeply involved in the secretory function and/or its regulation.