Association of midgestation paraoxonase 1 activity and pregnancies complicated by preterm birth

• Published in: American journal of obstetrics and gynecology Vol. 203; no. 3; pp. 246.e1 - 246.e4
• Main Authors: Baker, Arthur M., MD, Haeri, Sina, MD, MHSA, Klein, Richard L., PhD, Boggess, Kim, MD
• Format: Journal Article Conference Proceeding
• Language: English
• Published: New York, NY Elsevier Inc 01.09.2010; Elsevier
• Subjects: Adult; Aryldialkylphosphatase - blood; Biological and medical sciences; Case-Control Studies; Diseases of mother, fetus and pregnancy; Female; Gestational Age; Gynecology. Andrology. Obstetrics; Humans; Lipids - blood; Medical sciences; Obstetrics and Gynecology; oxidative stress; Paraoxon - blood; paraoxonase 1; Phenylacetates - blood; Pregnancy; Pregnancy. Fetus. Placenta; Premature Birth - blood; preterm birth; Retrospective Studies; paraoxonase 1; preterm birth; oxidative stress; Pregnancy; Pregnancy disorders; Prematurity; Gynecology; Premature delivery; Complication; Obstetrics
• ISSN: 0002-9378; 1097-6868
• DOI: 10.1016/j.ajog.2010.04.048

Objective The objective of the study was to determine whether an association exists between low paraoxonase 1 activity and dyslipidemia at midgestation and preterm birth. Study Design We conducted a case-control study of 30 women with preterm birth and 90 women with uncomplicated term deliveries. Maternal serum collected at 15-20 weeks was used to measure lipid concentrations and paraoxonase 1 activity using 2 substrates: paraoxon and phenylacetate (arylesterase activity). Results The groups did not differ with respect to maternal demographics. Paraoxonase 1 activity (paraoxon) was significantly lower in women delivering preterm compared with controls (12.9 ± 6.1 vs 16.6 ± 7.7 dA/min; P = .02). Arylesterase activity and serum lipid concentrations were similar between women with preterm birth and controls. Conclusion Midgestation paraoxonase 1 activity is lower in women who later experience spontaneous preterm birth compared with women who have term deliveries. Prospective studies are needed to determine the significance of paraoxonase 1 in the pathogenesis of preterm birth.