Interleukin-8 is increased in the membrane of circulating erythrocytes in patients with acute coronary syndrome
Aims Studies have shown that erythrocyte membranes are present within necrotic cores in atherosclerotic plaques, and that circulating erythrocytes in patients with acute coronary syndrome (ACS) have increased total cholesterol content (CEM). Interleukin-8 (IL-8) binds to erythrocytes and during intr...
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Published in | European heart journal Vol. 29; no. 22; pp. 2713 - 2722 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
England
Oxford University Press
01.11.2008
Oxford Publishing Limited (England) |
Subjects | |
Online Access | Get full text |
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Summary: | Aims Studies have shown that erythrocyte membranes are present within necrotic cores in atherosclerotic plaques, and that circulating erythrocytes in patients with acute coronary syndrome (ACS) have increased total cholesterol content (CEM). Interleukin-8 (IL-8) binds to erythrocytes and during intraplaque haemorrhage it is released into the plaque and thus may contribute to inflammatory cascade and atherosclerotic plaque instability. The present study was undertaken to test the hypothesis that erythrocyte membrane IL-8 is elevated in patients with ACS compared with those with chronic stable angina (CSA). Methods and results Consecutive patients who presented with CSA (n = 120, 92 men, 62 ± 9 years), ACS (n = 118, 90 men, 62 ± 10 years) or with chest pain who had normal coronary arteries (n = 36, 26 men, 60 ± 7 years), were studied prospectively. IL-8 concentrations in erythrocyte membranes (rIL-8) and in plasma (pIL-8), C-reactive protein (CRP) and CEM were measured. rIL-8 levels [mean ± 1 SD (standard deviation)] were higher in ACS (102.9 ± 70.1 pg/mL) compared with CSA (44.7 ± 22.8 pg/mL) (P < 0.001). No difference in pIL-8 levels between the two coronary artery disease groups was observed (P = 0.280). Serum CRP levels were correlated with rIL-8 levels (r = 0.294, P < 0.001); no association was found between CRP and pIL-8 levels (r = 0.025, P = 0.706). Further, rIL-8 had an independent association with ACS, when CRP and CEM were taken into consideration. Conclusion This study shows for the first time that rIL-8 content was significantly higher in ACS, compared with CSA. These findings endorse results from our previous studies suggesting that erythrocytes may play an important role in the development of unstable atherosclerotic plaque. |
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Bibliography: | Related-article-href:10.1093/eurheartj/ehn469 istex:1D3E030B4E67E4ED64146EA4F1A9E6C7D74BDC76 related-article-ID:RA1 ArticleID:ehn382 ark:/67375/HXZ-3C2X6162-M ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0195-668X 1522-9645 |
DOI: | 10.1093/eurheartj/ehn382 |