Synthesis and characterization of single-phase silicon-substituted α-tricalcium phosphate

• Published in: Biomaterials Vol. 27; no. 15; pp. 2916 - 2925
• Main Authors: Reid, Joel W., Tuck, Loughlin, Sayer, Michael, Fargo, Karen, Hendry, Jason A.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.05.2006
• Subjects: Bioceramics; Bone Substitutes - analysis; Bone Substitutes - chemistry; Calcium Phosphates - analysis; Calcium Phosphates - chemistry; Crystallization - methods; Hydroxyapatite; Materials Testing; Molecular Conformation; Particle Size; Phase Transition; Rietveld refinement; Silicon; Silicon - chemistry; Tricalcium phosphate; α-TCP; Bioceramics; Tricalcium phosphate; Hydroxyapatite; Silicon; Rietveld refinement; α-TCP
• ISSN: 0142-9612; 1878-5905
• DOI: 10.1016/j.biomaterials.2006.01.007

Silicon-substituted calcium phosphate (CaP) powders with a Ca/(P+Si) ratio of 1.50 have been prepared by a wet chemical method, with silicon contents up to 2.16 weight percent (wt%). Sintering for 2 h at 1250 °C yields single-phase silicon-substituted alpha tricalcium phosphate (Si- α-TCP) for compositions between 0.59 and 1.14 wt% silicon. The sintered powders have been characterized with X-ray fluorescence (XRF) spectrometry, X-ray diffraction (XRD), attenuated total reflection infrared spectroscopy (ATR-IR) and transmission electron microscopy (TEM). Compositions with less than 0.59 wt% silicon result in mixtures of Si- α-TCP, β-TCP, and calcium hydroxyapatite (HA), while compositions with more than 1.14 wt% silicon result in mixtures of Si- α-TCP and HA. The lattice parameters of single-phase Si- α-TCP prepared with 0.87 wt% silicon are a = 1 2.8 7 4 ( 1 ) Å , b = 2 7.3 7 2 ( 2 ) Å , c = 1 5.2 2 5 ( 1 ) Å , and β = 1 2 6.3 8 ( 1 ) ° .