Discovery of pyrazolo[1,5-a]pyrimidine-based Pim inhibitors: A template-based approach
The synthesis and SAR development of a class of pyrazolo[1,5-a]pyrimidine-based Pim kinase inhibitors are detailed from an early HTS hit to a pan–Pim inhibitor such as 11j. The synthesis and hit-to-lead SAR development from a pyrazolo[1,5-a]pyrimidine-derived hit 5 to the identification of a series...
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Published in | Bioorganic & medicinal chemistry letters Vol. 23; no. 22; pp. 6178 - 6182 |
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Main Authors | , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
OXFORD
Elsevier Ltd
15.11.2013
Elsevier |
Subjects | |
Online Access | Get full text |
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Summary: | The synthesis and SAR development of a class of pyrazolo[1,5-a]pyrimidine-based Pim kinase inhibitors are detailed from an early HTS hit to a pan–Pim inhibitor such as 11j.
The synthesis and hit-to-lead SAR development from a pyrazolo[1,5-a]pyrimidine-derived hit 5 to the identification of a series of potent, pan–Pim inhibitors such as 11j are described. |
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Bibliography: | http://dx.doi.org/10.1016/j.bmcl.2013.08.110 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Article-2 ObjectType-Feature-1 INDUSTRY |
ISSN: | 0960-894X 1464-3405 |
DOI: | 10.1016/j.bmcl.2013.08.110 |