Hepatic epithelioid hemangioendothelioma: Dilemma and challenges in the preoperative diagnosis

Hepatic epithelioid hemangioendothelioma(HEHE) is a rare category of vascular tumor with uncertain malignant potential. It commonly presents nonspecific and variable clinical manifestations, ranging from asymptomatic to hepatic failure. In addition, laboratory measurements and imaging features also...

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Published inWorld journal of gastroenterology : WJG Vol. 22; no. 41; pp. 9247 - 9250
Main Authors Hu, Hai-Jie, Jin, Yan-Wen, Jing, Qiu-Yang, Shrestha, Anuj, Cheng, Nan-Sheng, Li, Fu-Yu
Format Journal Article
LanguageEnglish
Published United States Baishideng Publishing Group Inc 07.11.2016
Subjects
Adult
Antigens, CD34 - analysis
Biomarkers, Tumor - analysis
Biopsy
Female
Hemangioendothelioma, Epithelioid - diagnosis
Hemangioendothelioma, Epithelioid - diagnostic imaging
Hemangioendothelioma, Epithelioid - pathology
Hemangioendothelioma, Epithelioid - surgery
Hepatectomy
Humans
Immunohistochemistry
Letters To The Editor
Liver Neoplasms - diagnosis
Liver Neoplasms - diagnostic imaging
Liver Neoplasms - pathology
Liver Neoplasms - surgery
Platelet Endothelial Cell Adhesion Molecule-1 - analysis
Positron Emission Tomography Computed Tomography
Predictive Value of Tests
Tomography, X-Ray Computed
Ultrasonography
Vascular tumors
Hepatic epithelioid hemangioendothelioma
Diagnosis
Dilemma
Challenges
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Summary:Hepatic epithelioid hemangioendothelioma(HEHE) is a rare category of vascular tumor with uncertain malignant potential. It commonly presents nonspecific and variable clinical manifestations, ranging from asymptomatic to hepatic failure. In addition, laboratory measurements and imaging features also lack specificity in the diagnosis of HEHE. The aim of the present study is to highlight the dilemma and challenges in the preoperative diagnosis of HEHE, and to enhance awareness of the range of hepatobiliary surgery available in patients with multiple hepatic nodular lesions on imaging. In these patients, HEHE should at least be considered in the differential diagnosis.
Bibliography:Hai-Jie Hu;Yan-Wen Jin;Qiu-Yang Jing;Anuj Shrestha;Nan-Sheng Cheng;Fu-Yu Li;Department of Biliary Surgery, West China Hospital of Sichuan University;Department of Pathology, West China Hospital of Sichuan University;Department of General Surgery, Gandaki Medical College
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ObjectType-Report-1
Author contributions: Hu HJ and Jin YW contributed equally to this paper; Hu HJ and Jin YW contributed to data acquisition and drafted the manuscript; Jing QY contributed to data acquisition; Shrestha A and Cheng NS were involved in the revision of the manuscript; Li FY conceived and designed the study and revised the manuscript.
Telephone: + 86-28-85422465 Fax: +86-28-85422465
Correspondence to: Fu-Yu Li, MD, PhD, Department of Biliary Surgery, West China Hospital of Sichuan University, 37 Guoxue Xiang, Wuhou District, Chengdu 610041, Sichuan Province, China. lfy_74@hotmail.com
Supported by National Nature Science of China, No. 30801111; Science and Technology Support Project of Sichuan Province, No. 2014SZ0002-10.
ISSN:1007-9327
2219-2840
2219-2840
DOI:10.3748/wjg.v22.i41.9247