Age-specific vaccination coverage estimates for influenza, human papillomavirus and measles containing vaccines from seven population-based healthcare databases from four EU countries – The ADVANCE project

• Published in: Vaccine Vol. 38; no. 16; pp. 3243 - 3254
• Main Authors: Braeye, Toon, Emborg, Hanne-Dorthe, Llorente-García, Ana, Huerta, Consuelo, Martín-Merino, Elisa, Duarte-Salles, Talita, Danieli, Giorgia, Tramontan, Lara, Weibel, Daniel, McGee, Chris, Villa, Marco, Gini, Rosa, Lehtinen, Matti, Titievsky, Lina, Sturkenboom, Miriam
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 03.04.2020; Elsevier Limited
• Subjects: Adolescent; Age; Age Factors; Aged; Alphapapillomavirus; Birth; Child; Cohort Studies; Collaboration; Computer networks; Delivery of Health Care; Electronic health records; Estimates; Europe - epidemiology; Health care; Human papillomavirus; Humans; Hypothesis testing; Influenza; Influenza vaccines; Influenza, Human - epidemiology; Influenza, Human - prevention & control; Italy - epidemiology; Measles; Measles vaccines; Papillomaviridae; Papillomavirus Vaccines; Pertussis Vaccine; Population; Population studies; Probabilistic methods; Probability; Public health; Retrospective Studies; Spain; Vaccination; Vaccination Coverage; Vaccines; Weighting methods; Whooping cough; Italy; Europe; Spain; Influenza vaccines; Probability; Papillomavirus vaccines; Vaccination coverage; Measles vaccines
• ISSN: 0264-410X; 1873-2518
• DOI: 10.1016/j.vaccine.2020.02.082

The Accelerated Development of VAccine beNefit-risk Collaboration in Europe (ADVANCE) is a public–private collaboration aiming to develop and test a system for rapid benefit-risk monitoring of vaccines using existing healthcare databases in Europe. We estimated vaccine coverage from electronic healthcare databases as part of a fit-for-purpose assessment for vaccine benefit-risk studies. A retrospective dynamic cohort study was conducted through a distributed network approach. Coverage with measles-vaccine for birth year 2006, human papillomavirus (HPV)-vaccine for birth years 1990–2000 and influenza-vaccine for birth years 1920–1950 was estimated using period-prevalence and inverse probability weighting methods. Seven databases from four countries participated: Italy (Pedianet, Val Padana), Spain (BIFAP, SIDIAP), UK (RCGP-RSC, THIN), Denmark (SSI/AUH). Database access providers extracted the data, transformed it into a common structure and ran an R-script locally. The created output tables were shared and pooled at a central server. The total study population comprised 274,616 persons for measles-vaccine, 2,011,666 persons for HPV-vaccine and 14,904,033 persons for influenza-vaccine. Measles-vaccine coverage varied from 84.3% (Denmark) to 96.5% (Italy, Val Padana) for the first dose and from 82.8% (Italy, Val Padana) to 90.9% (UK) for the second dose at the age of 7 years. The HPV-vaccine coverage, aggregated over birth years 1997–2000, ranged from 60% (UK) to 88.3% (Denmark) at the age of 15 years. The influenza-vaccine coverage for the influenza seasons from 2009 to 2015 for persons aged 65 years and more was roughly stable around 43% in Denmark and around 68% in the UK while a decrease from 58 to 50% was observed in Catalonia (Spain). We obtained detailed, age-specific coverage estimates though a common procedure. We discussed between database comparability and comparability to published national estimates.