Prolonged neutrophil dysfunction after Plasmodium falciparum malaria is related to hemolysis and heme oxygenase-1 induction

• Published in: The Journal of immunology (1950) Vol. 189; no. 11; pp. 5336 - 5346
• Main Authors: Cunnington, Aubrey J, Njie, Madi, Correa, Simon, Takem, Ebako N, Riley, Eleanor M, Walther, Michael
• Format: Journal Article
• Language: English
• Published: United States 01.12.2012
• Subjects: Acute Disease; Antigens, CD - blood; Antigens, Differentiation, Myelomonocytic - blood; Child; Child, Preschool; Coinfection; Erythrocyte Count; Female; Gene Expression; Haptoglobins - analysis; Heme - analysis; Heme Oxygenase-1 - genetics; Heme Oxygenase-1 - immunology; Hemolysis - immunology; Hemopexin - analysis; Humans; Malaria, Falciparum - immunology; Malaria, Falciparum - parasitology; Malaria, Falciparum - pathology; Male; Neutrophils - immunology; Neutrophils - metabolism; Neutrophils - pathology; Plasmodium falciparum; Plasmodium falciparum - immunology; Receptors, Cell Surface - blood; Respiratory Burst - immunology; Salmonella; Salmonella - immunology; Salmonella Infections - immunology; Salmonella Infections - microbiology; Salmonella Infections - pathology; Up-Regulation

It is not known why people are more susceptible to bacterial infections such as nontyphoid Salmonella during and after a malaria infection, but in mice, malarial hemolysis impairs resistance to nontyphoid Salmonella by impairing the neutrophil oxidative burst. This acquired neutrophil dysfunction is...