Neuroprotective Effects of Chemical Constituents of Leaves of Euonymus hamiltonianus Wall

Wall. is considered a medicinal plant and is used to treat pain, cough, dysuria, and cancer, but a clear phytochemical investigation of its biological activities has yet to be performed. Investigation of chemical constituents of the leaves of Wall. led to the isolation of three new compounds by chro...

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Published inPlants (Basel) Vol. 13; no. 8; p. 1094
Main Authors Tran, Huynh Nguyen Khanh, Yu, Jae Sik, Huang, Tianqi, Lee, Gakyung, Choi, Hyo Sun, Yang, Hyun Ok
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 13.04.2024
MDPI
Subjects
Acids
beta amyloid
Biological activity
Chemical compounds
Chromatography
Cognitive ability
Constituents
Cough
COX-2
Cyclooxygenase-2
Euonymus
Euonymus hamiltonianus
Flavonoids
flavonols
Flowers & plants
Herbal medicine
iNOS
Leaves
Medicinal plants
Natural products
Neuroprotection
Nitric oxide
Nitric-oxide synthase
NMR
Nuclear magnetic resonance
Phytochemicals
Spectroscopic techniques
Spectroscopy
Tumor necrosis factor-TNF
β-Amyloid
NO
Euonymus hamiltonianus
iNOS
COX-2
beta amyloid
flavonols
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Summary:Wall. is considered a medicinal plant and is used to treat pain, cough, dysuria, and cancer, but a clear phytochemical investigation of its biological activities has yet to be performed. Investigation of chemical constituents of the leaves of Wall. led to the isolation of three new compounds by chromatography techniques, euonymusins A-C ( , , and ), and the acquisition of new spectroscopic data for euonymusin D ( ), along with the identification of ten known compounds. The chemical structures of the compounds were established using extensive spectroscopic techniques, including NMR, MS, and hydrolysis, and compared with the published data. These compounds were tested in vitro for their inhibitory effects on beta amyloid production (Aβ42). Compounds and displayed weak inhibition, with IC values ranging from 53.15 to 65.43 µM. Moreover, these compounds were also assessed for their inhibitory effects on nitric oxide production. Of these compounds, , , and displayed inhibitory effects on NO production, with IC values ranging from 14.38 to 17.44 µM. Compounds , , and also suppressed LPS-induced expression of nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) protein.
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These authors contributed equally to this work.
ISSN:2223-7747
2223-7747
DOI:10.3390/plants13081094