Tumor budding is a valuable prognostic parameter in endometrial carcinomas

• Published in: Indian journal of pathology & microbiology Vol. 65; no. 4; pp. 851 - 855
• Main Authors: Ocal, Irfan, Guzelis, Ismail
• Format: Journal Article
• Language: English
• Published: Mumbai Wolters Kluwer India Pvt. Ltd 01.10.2022; Medknow Publications and Media Pvt. Ltd; Medknow Publications & Media Pvt. Ltd; Wolters Kluwer Medknow Publications
• Subjects: Cancer; Carcinoma; early stage; Endometrial cancer; endometrial carcinoma; Endometrium; Health aspects; Hysterectomy; lymph node involvement; Lymph nodes; lymphovascular invasion; Medical prognosis; Myometrium; Parameters; Prognosis; Rank tests; Statistical analysis; tumor budding; Tumors; Uterine cancer; Women; Early stage; endometrial carcinoma; lymphovascular invasion; prognosis; lymph node involvement; tumor budding
• ISSN: 0377-4929; 0974-5130
• DOI: 10.4103/ijpm.ijpm_109_21

Background: Tumor budding (TB) is a morphological finding believed to play an important role in determining the prognosis in many cancers. Aim: Our aim is to evaluate the prognostic importance of TB in endometrial carcinomas. Settings and Design: Two-hundred-eleven endometrial cancers were obtained from 2008 to 2015 that were comprised of those having undergone surgical staging with a hysterectomy and at least 5 years followed up. Material and Methods: All hematoxylin and eosin stained slides were reevaluated for the status of TB. Statistical Analysis: Nonparametric tests, the Kaplan-Meier method, the Log-rank test, and Cox proportional hazard regression were used. Results and Conclusion: TB was found to correlated with larger diameter (P = 0.000), nonendometrioid (P = 0.038), mixed cell types (P = 0.005), higher grade (P = 0.000), deeper invasion of the myometrium (P = 0.000), cervical stromal invasion (P = 0.000), advanced pT (P = 0.011), lymph node involvement (P = 0.000), lymphovascular invasion (P = 0.000), and advanced stage (P = 0.000). The presence of TB worsens the 5-year overall survival (OS) (P = 0.0001). In cases such as grade 1, pT1, or stage 1 endometrial carcinomas, the presence of TB decreases the OS rate (P = 0.00017, P = 0.0016, P < 0.0001). Our result suggested that the presence of TB adversely affects the prognosis. It was concluded that TB could be a valuable prognostic parameter.