New Copper, Palladium and Nickel Catalytic Systems: An Evolution towards More Efficient Procedures

• Published in: Chemical record Vol. 16; no. 3; pp. 1082 - 1095
• Main Authors: SanMartin, Raul, Herrero, María Teresa, Domínguez, Esther
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.06.2016; Wiley Subscription Services, Inc
• Subjects: copper; homogeneous catalysis; Nickel; palladium; sustainable chemistry; nickel; copper; palladium; sustainable chemistry; homogeneous catalysis
• ISSN: 1527-8999; 1528-0691
• DOI: 10.1002/tcr.201500289

Metal‐catalysed reactions are a fundamental tool in synthetic chemistry. Increasingly challenging transformations can be accomplished only by means of certain metal catalysts. However, there still remains the need for a substantial decrease of the amount of catalyst, for better reuse or recycling of such active species, and for the avoidance of relatively toxic solvents in favour of environmentally friendly media. These facts apply to copper‐, palladium‐, and nickel‐catalysed cross‐coupling reactions, direct arylations, and oxidative processes. This account summarises our research on the last reactions, featuring an evolution towards more sustainable procedures in this field. Efficiency is the key: A summary of the development of new metal‐catalyzed arylation (O‐, S‐, and N‐arylations; α‐arylation of ketone enolates; Suzuki biaryl coupling; direct arylation of (hetero)arenes) and oxidation procedures, with a focus on catalyst loadings and more sustainable reagents/reaction media, is presented.