LABEL-FREE 3D OPTICAL MICROANGIOGRAPHY IMAGING OF FUNCTIONAL VASA NERVORUM AND PERIPHERAL MICROVASCULAR TREE IN THE HIND LIMB OF DIABETIC MICE

Diabetic neuropathy (DN) is, at least in part, associated with the functional attenuation of vasa nervorum, the microvascular structure of peripheral nerves. Microvascular imaging options for vasa nervorum still remain limited. In this work, optical microangiography (OMAG), a volumetric, label-free...

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Published inJournal of innovative optical health science Vol. 3; no. 4; pp. 307 - 313
Main Authors JIA, YALI, BAUMANN, THOMAS K., WANG, RUIKANG K.
Format Journal Article
LanguageEnglish
Published Singapore World Scientific Publishing Company 01.10.2010
Subjects
Vasa nervorum
optical microangiography
peripheral nerve
microcirculation
diabetes
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Summary:Diabetic neuropathy (DN) is, at least in part, associated with the functional attenuation of vasa nervorum, the microvascular structure of peripheral nerves. Microvascular imaging options for vasa nervorum still remain limited. In this work, optical microangiography (OMAG), a volumetric, label-free imaging technique, is utilized for characterizing, with high resolution, blood perfusion of peripheral nerve in diabetic mice. We demonstrate that OMAG is able to visualize the structure of microvasculature and to quantify the changes of dynamic blood flow and vessel diameters during administration of vessel stimulant in both diabetic and normal mice. The results indicate the potential of OMAG to assess the blood supply of nerve involved in the pathology and treatment of DN.
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ISSN:1793-5458
1793-7205
DOI:10.1142/S1793545810001167