Morphine-3-glucuronide prevents tolerance to morphine-6-glucuronide in mice

Daily subcutaneous (s.c.) pretreatment with morphine-3-glucuronide (6 mg/kg) was found to reduce morphine-6-glucuronide (4 mg/kg s.c.)-induced antinociception, with no decrease in the effect over 5 days. Morphine-6-glucuronide administration (4 mg/kg s.c.) on Day 6, without morphine-3-glucorinide pr...

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Bibliographic Details
Published inEuropean journal of pain Vol. 1; no. 2; p. 161
Main Authors Faura, C C, Olaso, M J, Horga, J F
Format Journal Article
LanguageEnglish
Published England 1997
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Summary:Daily subcutaneous (s.c.) pretreatment with morphine-3-glucuronide (6 mg/kg) was found to reduce morphine-6-glucuronide (4 mg/kg s.c.)-induced antinociception, with no decrease in the effect over 5 days. Morphine-6-glucuronide administration (4 mg/kg s.c.) on Day 6, without morphine-3-glucorinide pretreatment, results in a significant increase in antinociception (from 24% on Day 5 to 70%; p< or =0.05). Morphine-3-glucuronide may prevent tolerance to morphine-6-glucuronide by reducing morphine-6-glucuronide-induced antinociception.
ISSN:1090-3801
DOI:10.1016/S1090-3801(97)90074-4