Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: implications for drug delivery and activity in cancer chemotherapy

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Bibliographic Details
Published inMolecular carcinogenesis Vol. 13; no. 3; p. 129
Main Authors Wacher, V J, Wu, C Y, Benet, L Z
Format Journal Article
LanguageEnglish
Published United States 01.07.1995
Subjects
Antineoplastic Agents - administration & dosage
Antineoplastic Agents - metabolism
Aryl Hydrocarbon Hydroxylases
ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism
Cytochrome P-450 CYP3A
Cytochrome P-450 Enzyme System - metabolism
Drug Resistance, Multiple
Epoxide Hydrolases - metabolism
Gene Expression
Glutathione Transferase - metabolism
Humans
Liver - metabolism
Neoplasms - drug therapy
Oxidoreductases, N-Demethylating - metabolism
Substrate Specificity
Tissue Distribution
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ISSN:0899-1987
DOI:10.1002/mc.2940130302