Gut Microbiota and Atherosclerosis—Focusing on the Plaque Stability

Cardiovascular diseases (CVDs) are major causes of mortality and morbidity in the modern society. The rupture of atherosclerotic plaque can induce thrombus formation, which is the main cause of acute cardiovascular events. Recently, many studies have demonstrated that there are some relationships be...

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Published inFrontiers in cardiovascular medicine Vol. 8; p. 668532
Main Authors Shen, Xinyi, Li, Lihua, Sun, Zhen, Zang, Guangyao, Zhang, Lili, Shao, Chen, Wang, Zhongqun
Format Journal Article
LanguageEnglish
Published Frontiers Media S.A 03.08.2021
Subjects
atherosclerosis
Cardiovascular Medicine
gut microbiota
metabolites
plaque stability
therapies
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Summary:Cardiovascular diseases (CVDs) are major causes of mortality and morbidity in the modern society. The rupture of atherosclerotic plaque can induce thrombus formation, which is the main cause of acute cardiovascular events. Recently, many studies have demonstrated that there are some relationships between microbiota and atherosclerosis. In this review, we will focus on the effect of the microbiota and the microbe-derived metabolites, including trimethylamine-N-oxide (TMAO), short-chain fatty acids (SCFAs), and lipopolysaccharide (LPS), on the stability of atherosclerotic plaque. Finally, we will conclude with some therapies based on the microbiota and its metabolites.
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Reviewed by: Jun-ichiro Koga, Kyushu University, Japan; Christoph Eugen Hagemeyer, Monash University, Australia; Sudhahar Varadarajan, Augusta University, United States
Edited by: Tohru Fukai, Augusta University, United States
This article was submitted to Atherosclerosis and Vascular Medicine, a section of the journal Frontiers in Cardiovascular Medicine
ISSN:2297-055X
2297-055X
DOI:10.3389/fcvm.2021.668532