Blunted HPA axis responsiveness to stress in atopic patients is associated with the acuity and severeness of allergic inflammation

Research highlights ► Atopy is linked to reduced HPA axis responsiveness. ► In SAR patients reduced HPA axis reactivity is only evident during acute allergic inflammation. ► Atopy is linked to reduced hypothalamus-pitutitary-adrenal (HPA) axis responsiveness. ► Hyporesponsiveness of the HPA axis is...

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Published inBrain, behavior, and immunity Vol. 24; no. 8; pp. 1347 - 1353
Main Authors Buske-Kirschbaum, A, Ebrecht, M, Hellhammer, D.H
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Inc 01.11.2010
Subjects
Acuity
Adult
Allergy and Immunology
Chronic (allergic) inflammation
Cortisol
Female
Humans
Hydrocortisone - blood
Hypersensitivity, Immediate - physiopathology
Hypothalamo-Hypophyseal System - physiopathology
Hypothalamus–pituitary–adrenal (HPA) axis
Immunoglobulin E - blood
Inflammation - physiopathology
Leukocyte Count
Leukocytes - immunology
Male
Pituitary-Adrenal System - physiopathology
Pollen - immunology
Psychiatry
Rhinitis, Allergic, Seasonal - physiopathology
Seasonal allergic rhinitis (SAR)
Social Environment
Stress
Stress, Psychological - physiopathology
Seasonal allergic rhinitis (SAR)
Chronic (allergic) inflammation
Cortisol
Hypothalamus–pituitary–adrenal (HPA) axis
Stress
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Summary:Research highlights ► Atopy is linked to reduced HPA axis responsiveness. ► In SAR patients reduced HPA axis reactivity is only evident during acute allergic inflammation. ► Atopy is linked to reduced hypothalamus-pitutitary-adrenal (HPA) axis responsiveness. ► Hyporesponsiveness of the HPA axis is only evident during the acute allergic inflammatory state.
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ISSN:0889-1591
1090-2139
DOI:10.1016/j.bbi.2010.06.013