An ethanol extract of Lysimachia mauritiana exhibits inhibitory activity against hepatitis E virus genotype 3 replication

Hepatitis E virus (HEV) is an etiological agent of acute hepatitis E, a self-limiting disease prevalent in developing countries. HEV can cause fulminant hepatic failure with high mortality rates in pregnant women, and genotype 3 is reported to trigger chronic hepatitis in immunocompromised individua...

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Published in	The journal of microbiology Vol. 55; no. 12; pp. 984 - 988
Main Authors	Jin, Seong Eun, Kim, Jung-Eun, Kim, Sun Yeou, Park, Bang Ju, Song, Yoon-Jae
Format	Journal Article
Language	English
Published	Seoul The Microbiological Society of Korea 01.12.2017 Springer Nature B.V 한국미생물학회
Subjects	Antiviral agents Biomedical and Life Sciences chronic hepatitis Cytotoxicity Developing countries Disease control Drug development Drugs Ethanol etiological agents Etiology genotype Genotype & phenotype Genotypes Hepatitis hepatitis E immunocompromised population LDCs Life Sciences liver failure Lysimachia Lysimachia mauritiana Microbiology mortality Orthohepevirus A Plant extracts Pregnancy pregnant women Replication replicon screening Swine Virology Viruses Women 생물학 hepatitis E virus antiviral Lysimachia mauritiana
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ISSN	1225-8873 1976-3794 1976-3794
DOI	10.1007/s12275-017-7477-1

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Abstract	Hepatitis E virus (HEV) is an etiological agent of acute hepatitis E, a self-limiting disease prevalent in developing countries. HEV can cause fulminant hepatic failure with high mortality rates in pregnant women, and genotype 3 is reported to trigger chronic hepatitis in immunocompromised individuals worldwide. Screening of plant extracts for compounds with potential anti-HEV effects led to the identification of a 70% ethanol extract of Lysimachia mauritiana (LME) that interferes with replication of the swine HEV genotype 3 replicon. Furthermore, LME significantly inhibited replication of HEV genotype 3 and expression of HEV ORF2 in infected cells without exerting cytotoxic effects. Collectively, our findings demonstrate the potential utility of LME in the development of novel antiviral drugs against HEV infection.
AbstractList	Hepatitis E virus (HEV) is an etiological agent of acute hepatitis E, a self-limiting disease prevalent in developing countries. HEV can cause fulminant hepatic failure with high mortality rates in pregnant women, and genotype 3 is reported to trigger chronic hepatitis in immunocompromised individuals worldwide. Screening of plant extracts for compounds with potential anti-HEV effects led to the identification of a 70% ethanol extract of Lysimachia mauritiana (LME) that interferes with replication of the swine HEV genotype 3 replicon. Furthermore, LME significantly inhibited replication of HEV genotype 3 and expression of HEV ORF2 in infected cells without exerting cytotoxic effects. Collectively, our findings demonstrate the potential utility of LME in the development of novel antiviral drugs against HEV infection. Hepatitis E virus (HEV) is an etiological agent of acute hepatitis E, a self-limiting disease prevalent in developing countries. HEV can cause fulminant hepatic failure with high mortality rates in pregnant women, and genotype 3 is reported to trigger chronic hepatitis in immunocompromised individuals worldwide. Screening of plant extracts for compounds with potential anti-HEV effects led to the identification of a 70% ethanol extract of Lysimachia mauritiana (LME) that interferes with replication of the swine HEV genotype 3 replicon. Furthermore, LME significantly inhibited replication of HEV genotype 3 and expression of HEV ORF2 in infected cells without exerting cytotoxic effects. Collectively, our findings demonstrate the potential utility of LME in the development of novel antiviral drugs against HEV infection. Hepatitis E virus (HEV) is an etiological agent of acute hepatitis E, a self-limiting disease prevalent in developing countries. HEV can cause fulminant hepatic failure with high mortality rates in pregnant women, and genotype 3 is reported to trigger chronic hepatitis in immunocompromised individuals worldwide. Screening of plant extracts for compounds with potential anti-HEV effects led to the identification of a 70% ethanol extract of Lysimachia mauritiana (LME) that interferes with replication of the swine HEV genotype 3 replicon. Furthermore, LME significantly inhibited replication of HEV genotype 3 and expression of HEV ORF2 in infected cells without exerting cytotoxic effects. Collectively, our findings demonstrate the potential utility of LME in the development of novel antiviral drugs against HEV infection.Hepatitis E virus (HEV) is an etiological agent of acute hepatitis E, a self-limiting disease prevalent in developing countries. HEV can cause fulminant hepatic failure with high mortality rates in pregnant women, and genotype 3 is reported to trigger chronic hepatitis in immunocompromised individuals worldwide. Screening of plant extracts for compounds with potential anti-HEV effects led to the identification of a 70% ethanol extract of Lysimachia mauritiana (LME) that interferes with replication of the swine HEV genotype 3 replicon. Furthermore, LME significantly inhibited replication of HEV genotype 3 and expression of HEV ORF2 in infected cells without exerting cytotoxic effects. Collectively, our findings demonstrate the potential utility of LME in the development of novel antiviral drugs against HEV infection. Hepatitis E virus (HEV) is an etiological agent of acute hepatitis E, a self-limiting disease prevalent in developing countries. HEV can cause fulminant hepatic failure with high mortality rates in pregnant women, and genotype 3 is reported to trigger chronic hepatitis in immunocompromised individuals worldwide. Screening of plant extracts for compounds with potential anti-HEV effects led to the identification of a 70% ethanol extract of Lysimachia mauritiana (LME) that interferes with replication of the swine HEV genotype 3 replicon. Furthermore, LME significantly inhibited replication of HEV genotype 3 and expression of HEV ORF2 in infected cells without exerting cytotoxic effects. Collectively, our findings demonstrate the potential utility of LME in the development of novel antiviral drugs against HEV infection. KCI Citation Count: 2
Author	Kim, Sun Yeou Kim, Jung-Eun Park, Bang Ju Jin, Seong Eun Song, Yoon-Jae
Author_xml	– sequence: 1 givenname: Seong Eun surname: Jin fullname: Jin, Seong Eun organization: Department of Life Science, Gachon University – sequence: 2 givenname: Jung-Eun surname: Kim fullname: Kim, Jung-Eun organization: Department of Life Science, Gachon University – sequence: 3 givenname: Sun Yeou surname: Kim fullname: Kim, Sun Yeou organization: College of Pharmacy, Gachon University, Gachon Institute of Pharmaceutical Science, Gachon University – sequence: 4 givenname: Bang Ju surname: Park fullname: Park, Bang Ju organization: Department of Electronic Engineering, Gachon University – sequence: 5 givenname: Yoon-Jae surname: Song fullname: Song, Yoon-Jae email: songyj@gachon.ac.kr organization: Department of Life Science, Gachon University
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Title	An ethanol extract of Lysimachia mauritiana exhibits inhibitory activity against hepatitis E virus genotype 3 replication
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