An ethanol extract of Lysimachia mauritiana exhibits inhibitory activity against hepatitis E virus genotype 3 replication

• Published in: The journal of microbiology Vol. 55; no. 12; pp. 984 - 988
• Main Authors: Jin, Seong Eun, Kim, Jung-Eun, Kim, Sun Yeou, Park, Bang Ju, Song, Yoon-Jae
• Format: Journal Article
• Language: English
• Published: Seoul The Microbiological Society of Korea 01.12.2017; Springer Nature B.V; 한국미생물학회
• Subjects: Antiviral agents; Biomedical and Life Sciences; chronic hepatitis; Cytotoxicity; Developing countries; Disease control; Drug development; Drugs; Ethanol; etiological agents; Etiology; genotype; Genotype & phenotype; Genotypes; Hepatitis; hepatitis E; immunocompromised population; LDCs; Life Sciences; liver failure; Lysimachia; Lysimachia mauritiana; Microbiology; mortality; Orthohepevirus A; Plant extracts; Pregnancy; pregnant women; Replication; replicon; screening; Swine; Virology; Viruses; Women; 생물학; hepatitis E virus; antiviral; Lysimachia mauritiana
• ISSN: 1225-8873; 1976-3794; 1976-3794
• DOI: 10.1007/s12275-017-7477-1

Hepatitis E virus (HEV) is an etiological agent of acute hepatitis E, a self-limiting disease prevalent in developing countries. HEV can cause fulminant hepatic failure with high mortality rates in pregnant women, and genotype 3 is reported to trigger chronic hepatitis in immunocompromised individuals worldwide. Screening of plant extracts for compounds with potential anti-HEV effects led to the identification of a 70% ethanol extract of Lysimachia mauritiana (LME) that interferes with replication of the swine HEV genotype 3 replicon. Furthermore, LME significantly inhibited replication of HEV genotype 3 and expression of HEV ORF2 in infected cells without exerting cytotoxic effects. Collectively, our findings demonstrate the potential utility of LME in the development of novel antiviral drugs against HEV infection.