Sesquiterpenoids and xanthones derivatives produced by sponge-derived fungus Stachybotry sp. HH1 ZSDS1F1-2

• Published in: Journal of antibiotics Vol. 68; no. 2; pp. 121 - 125
• Main Authors: Qin, Chun, Lin, Xiuping, Lu, Xin, Wan, Junting, Zhou, Xuefeng, Liao, Shengrong, Tu, Zhengchao, Xu, Shihai, Liu, Yonghong
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.02.2015; Japan Antibiotics Research Assoc; Nature Publishing Group
• Subjects: 101/58; 631/92/349; 692/308/153; Animals; Anti-Inflammatory Agents - chemistry; Anti-Inflammatory Agents - isolation & purification; Anti-Inflammatory Agents - pharmacology; Antineoplastic Agents - chemistry; Antineoplastic Agents - isolation & purification; Antineoplastic Agents - pharmacology; Antiviral Agents - chemistry; Antiviral Agents - isolation & purification; Antiviral Agents - pharmacology; Bacteriology; Biomedical and Life Sciences; Bioorganic Chemistry; Biotechnology & Applied Microbiology; Cell Line, Tumor; Crystallography; Crystallography, X-Ray; Cyclooxygenase 2 Inhibitors - chemistry; Cyclooxygenase 2 Inhibitors - isolation & purification; Cyclooxygenase 2 Inhibitors - pharmacology; Cytotoxicity; Humans; Immunology; Life Sciences; Life Sciences & Biomedicine; Magnetic Resonance Spectroscopy; Medicinal Chemistry; Microbiology; Organic Chemistry; original-article; Pharmacology & Pharmacy; Porifera - microbiology; Science & Technology; Sesquiterpenes - chemistry; Sesquiterpenes - isolation & purification; Sesquiterpenes - pharmacology; Stachybotrys - isolation & purification; Stachybotrys - metabolism; Xanthones - chemistry; Xanthones - isolation & purification; Xanthones - pharmacology
• ISSN: 0021-8820; 1881-1469
• DOI: 10.1038/ja.2014.97

A new ( 2 ) and four known ( 1 , 8–10 ) sesquiterpenoids, two new ( 3 and 4 ) and eight known ( 5–7 , 11–15 ) xanthone derivatives were isolated from the cultures of sponge-derived fungus Stachybotry sp. HH1 ZDDS1F1-2. The structure of the compounds 1 – 15 was determined mainly by analysis of the one-dimensional and two-dimensional NMR spectroscopic data and by analogy with the data of those reported. Compound 1 was confirmed by X-ray crystallography. All the compounds were tested for their cytotoxic, antiinflammatory and antiviral (EV71) effects. Compounds 5 , 7 and 11 showed significant cytotoxicity against selected human tumor cell lines. Compounds 3 , 4 and 11 also displayed significant inhibitory activity against cycloooxygenase (COX-2). Compounds 4 , 5 and 11 showed activities against intestinal virus EV71.