The Emerging Scenario of Ferroptosis in Pancreatic Cancer Tumorigenesis and Treatment

• Published in: International journal of molecular sciences Vol. 25; no. 24; p. 13334
• Main Authors: Lyu, Hao, Kong, Jinghua, Chen, Jiasi, Zhang, Rui, Xiao, Shuai, Guo, Dong, Zhang, Qi, Chen, Xing-Zhen, Tang, Jingfeng, Zhou, Cefan
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 12.12.2024; MDPI
• Subjects: Animals; Antineoplastic Agents - pharmacology; Antineoplastic Agents - therapeutic use; Antioxidants; Apoptosis; Cancer; Carcinogenesis - metabolism; Care and treatment; Cell death; Dihydrofolate reductase; Drug therapy; Enzymes; Epigenetics; Family medical history; Fatty acids; Ferroptosis; Ferroptosis - drug effects; Homeostasis; Humans; Insulin Resistance; Kinases; Lipid peroxidation; Lipids; Medical prognosis; Metabolism; Metabolites; Mitochondria; Mutation; Pancreatic cancer; Pancreatic Neoplasms - drug therapy; Pancreatic Neoplasms - metabolism; Pancreatic Neoplasms - pathology; Pancreatitis; Pancreatitis - metabolism; Pancreatitis - pathology; Proteins; Review; Sapropterin dihydrochloride; Tumorigenesis; Type 2 diabetes; Zhang, Amy; pancreatic cancer; ferroptosis; drug resistance; tumorigenesis; immunotherapy
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms252413334

Pancreatic cancer remains one of the most lethal forms of cancer. Currently, there is a lack of effective drug treatments for pancreatic cancer. However, as a newly discovered form of non-apoptotic cell death, ferroptosis has garnered increasing attention in relation to pancreatic cancer. Understanding the role of ferroptosis in the tumorigenesis and treatment of pancreatic cancer may enable more effective clinical trials and treatments for pancreatic cancer and may minimize side effects or restrict the emergence of drug resistance. In this review, we summarize the current knowledge regarding the process and underlying mechanisms of ferroptosis, as well as its dual role in both promoting tumorigenesis and facilitating treatment strategies for pancreatic cancer. Additionally, how ferroptosis is implicated in the development of pancreatitis and insulin resistance, indicating that ferroptosis may play an important role in the risk of pancreatitis- and insulin-resistance-related pancreatic cancers, is also addressed.