Adipose Tissue Content of Marine N-3 Polyunsaturated Fatty Acids Is Inversely Associated With Myocardial Infarction

[...]the study supports the view that marine n-3 PUFA may protect against MI. Model A[low *] Model B[dagger] Content of EPA, % Q1 (0.00-0.07) 1.00 1.00 Q2 (>0.07-0.09) 0.98 (0.82-1.17) 0.93 (0.78-1.11) Q3 (>0.09-0.11) 0.83 (0.69-1.00) 0.77 (0.63-0.93) Q4 (>0.11-0.13) 0.92 (0.76-1.11) 0.84 (...

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Published inJournal of the American College of Cardiology Vol. 67; no. 8; pp. 1008 - 1009
Main Authors Gammelmark, Anders, MD, Nielsen, Michael S., MD, PhD, Bork, Christian S., MB, Lundbye-Christensen, Søren, MSc, PhD, Tjønneland, Anne, MD, PhD, DMSc, Overvad, Kim, MD, PhD, Schmidt, Erik B., MD, DMSc
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.03.2016
Elsevier Limited
Subjects
Adipose Tissue - chemistry
Adipose Tissue - cytology
Aged
Biopsy
Body fat
Cardiology
Cardiovascular
Cardiovascular disease
Chromatography, Gas
Confidence intervals
Family medical history
Fatty acids
Fatty Acids, Omega-3 - analysis
Female
Follow-Up Studies
Forecasting
Global Health
Heart attacks
Humans
Incidence
Internal Medicine
Male
Middle Aged
Myocardial Infarction - epidemiology
Myocardial Infarction - metabolism
Retrospective Studies
Studies
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Summary:[...]the study supports the view that marine n-3 PUFA may protect against MI. Model A[low *] Model B[dagger] Content of EPA, % Q1 (0.00-0.07) 1.00 1.00 Q2 (>0.07-0.09) 0.98 (0.82-1.17) 0.93 (0.78-1.11) Q3 (>0.09-0.11) 0.83 (0.69-1.00) 0.77 (0.63-0.93) Q4 (>0.11-0.13) 0.92 (0.76-1.11) 0.84 (0.68-1.04) Q5 (>0.13) 0.76 (0.63-0.91) 0.64 (0.50-0.82) Content of DPA, % Q1 (0.00-0.21) 1.00 1.00 Q2 (>0.21-0.25) 1.21 (1.01-1.45) 1.26 (1.05-1.51) Q3 (>0.25-0.29) 1.11 (0.91-1.36) 1.21 (0.97-1.50) Q4 (>0.29-0.34) 1.11 (0.92-1.34) 1.26 (1.02-1.56) Q5 (>0.34) 1.15 (0.94-1.40) 1.40 (1.08-1.80) Content of DHA, % Q1 (0.00-0.18) 1.00 1.00 Q2 (>0.18-0.23) 0.93 (0.77-1.12) 0.91 (0.75-1.09) Q3 (>0.23-0.29) 0.91 (0.75-1.09) 0.87 (0.71-1.05) Q4 (>0.29-0.37) 0.97 (0.81-1.17) 0.88 (0.72-1.08) Q5 (>0.37) 0.78 (0.64-0.95) 0.72 (0.56-0.94) Table 1 Adipose Tissue Content of Marine n-3 PUFA and Association With Myocardial Infarction Values are hazard ratios (95% confidence intervals) from the Cox proportional hazards model.DHA = docosahexaenoic acid; DPA = docosapentaenoic acid; EPA = eicosapentaenoic acid; PUFA = polyunsaturated fatty acids; Q = quintile.
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ISSN:0735-1097
1558-3597
DOI:10.1016/j.jacc.2015.12.014