Predictive value of DCE-MRI and IVIM-DWI in osteosarcoma patients with neoadjuvant chemotherapy
Objective To investigate the predictive value of dynamic contrast enhanced MRI (DCE-MRI) and intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) for clinical outcomes of osteosarcoma patients with neoadjuvant chemotherapy. Methods The present prospective single-arm cohort study enroll...
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Published in | Frontiers in oncology Vol. 12; p. 967450 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
Frontiers Media S.A
14.10.2022
|
Subjects | |
Online Access | Get full text |
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Summary: | Objective
To investigate the predictive value of dynamic contrast enhanced MRI (DCE-MRI) and intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) for clinical outcomes of osteosarcoma patients with neoadjuvant chemotherapy.
Methods
The present prospective single-arm cohort study enrolled 163 patients of osteosarcoma during July 2017 to July 2022. All patients received the same treatment strategy of neoadjuvant chemotherapy. Both DCE-MRI and IVIM-DWI were conducted for the patients before the chemotherapy, as well as after one or two chemotherapy treatment cycles. The imaging parameters of contrast agent transfer rate between blood and tissue (
K
trans
), contrast agent back-flux rate constant (
K
ep
), extravascular extracellular fractional volume (
V
e
), as well as pure diffusion coefficient (
D
value), pseudo-diffusion coefficient (
D*
value), apparent diffusion coefficient (
ADC
) and the perfusion fraction (
f
value) were recorded. RECIST standard [complete response (CR), partial response (PR), stable disease (SD), progressive disease (PD)] was used as the main clinical outcome.
Results
After two treatment cycles, 112 (68.71%) cases were with CR and PR, 31 (19.02%) cases were with SD and 20 cases (12.27%) were with PD. After 1~2 treatment cycles, patients with CR/PR showed significantly markedly lower
K
trans
,
K
ep
,
V
e
values, while higher
D
,
ADC
and
f
values compared with SD or PD patients. Alkaline phosphatase (ALP) and lactate dehydrogenase (LDH) were positively correlated with values of
K
trans
,
K
ep
, and
V
e
, while negative correlation was observed between ALP and values of
D
,
ADC
and
f
, as well as between LDH and
D
and
ADC
after the whole treatment.
D
and
K
ep
values after two treatment cycles showed the best predictive value for diagnosis of PD. The values of
K
tran
,
K
ep
,
ADC
as well as ALP and LDH were all risk factors for PD after neoadjuvant chemotherapy.
Conclusion
DCE-MRI and IVIM-DWI have the potential to predict clinical outcomes of osteosarcoma patients with neoadjuvant chemotherapy. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 This article was submitted to Surgical Oncology, a section of the journal Frontiers in Oncology Edited by: Boris Gala-Lopez, Dalhousie University, Canada Reviewed by: Marko Radulovic, Institute of Oncology and Radiology of Serbia, Serbia; Maria Paola Belfiore, University of Campania Luigi Vanvitelli, Italy |
ISSN: | 2234-943X 2234-943X |
DOI: | 10.3389/fonc.2022.967450 |