The Role and Regulation of the 11 Beta-Hydroxysteroid Dehydrogenase Enzyme System in Patients with Inflammatory Bowel Disease

• Published in: Digestive diseases and sciences Vol. 62; no. 12; pp. 3385 - 3390
• Main Authors: Hussey, M., Holleran, G., Smith, S., Sherlock, Mark, McNamara, D.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.12.2017; Springer; Springer Nature B.V
• Subjects: 11-beta-Hydroxysteroid Dehydrogenase Type 1 - metabolism; 11-beta-Hydroxysteroid Dehydrogenase Type 2 - metabolism; Adolescent; Adult; Aged; Aged, 80 and over; Analysis; Biochemistry; Carbohydrate Dehydrogenases - metabolism; Care and treatment; Colon - enzymology; Cortisone; Cytokines; Cytokines - metabolism; Dehydrogenases; Enzymes; Female; Gastroenterology; Gastrointestinal diseases; Gene expression; Hepatology; Humans; Inflammation; Inflammatory bowel disease; Inflammatory Bowel Diseases - enzymology; Isoenzymes; Male; Medicine; Medicine & Public Health; Middle Aged; Oncology; Original Article; Phosphates; Physiological aspects; Prospective Studies; Receptors, Glucocorticoid - metabolism; Studies; Transplant Surgery; Young Adult; Inflammatory bowel disease; 11 βeta-hydroxysteroid dehydrogenase; Metabolism; Glucocorticoid

Introduction Glucocorticoids are known to modulate a number of immunological responses including counteracting inflammation. Within tissues expressing the glucocorticoid and mineralocorticoid receptors including the colon, glucocorticoid metabolism is regulated by the isoenzymes of 11ß-hydroxysteroi...