Functional biodegradable polymers via ring-opening polymerization of monomers without protective groups

Biodegradable polymers are of current interest and chemical functionality in such materials is often demanded in advanced biomedical applications. Functional groups often are not tolerated in the polymerization process of ring-opening polymerization (ROP) and therefore protective groups need to be a...

Full description

Saved in:
Bibliographic Details
Published inChemical Society reviews Vol. 47; no. 2; pp. 7739 - 7782
Main Authors Becker, Greta, Wurm, Frederik R
Format Journal Article
LanguageEnglish
Published England Royal Society of Chemistry 15.10.2018
Subjects
Biodegradability
Biodegradable materials
Biomedical materials
Functional groups
Monomers
Organic chemistry
Polymerization
Polymers
Ring opening polymerization
Online AccessGet full text

Cover

More Information
Summary:Biodegradable polymers are of current interest and chemical functionality in such materials is often demanded in advanced biomedical applications. Functional groups often are not tolerated in the polymerization process of ring-opening polymerization (ROP) and therefore protective groups need to be applied. Advantageously, several orthogonally reactive functions are available, which do not demand protection during ROP. We give an insight into available, orthogonally reactive cyclic monomers and the corresponding functional synthetic and biodegradable polymers, obtained from ROP. Functionalities in the monomer are reviewed, which are tolerated by ROP without further protection and allow further post-modification of the corresponding chemically functional polymers after polymerization. Synthetic concepts to these monomers are summarized in detail, preferably using precursor molecules. Post-modification strategies for the reported functionalities are presented and selected applications highlighted. Functional polymers are reviewed which are accessible by the polymerization of reactive monomers. Their synthesis, polymerization, and post-polymerization modification are discussed.
Bibliography:Greta Becker studied biomedical chemistry at the University of Mainz, Germany, and at the Polymer Science and Engineering Department, the University of Massachusetts in Amherst, USA. She carried out her PhD research in the group of Dr Frederik R. Wurm at the Max Planck Institute for Polymer Research in Mainz, Germany and received her PhD degree in 2017. Great developed a series of degradable and polyfunctional polyphosphoesters for bioapplications. She was supported by a fellowship through funding of the Excellence Initiative (DFG/GSC 266) in the context of the graduate school of excellence "MAINZ" (Material Sciences in Mainz) and is currently working for Kuraray Europe GmbH.
Frederik R. Wurm (Priv.-Doz. Dr habil.) is currently heading the research group "Functional Polymers" at the Max Planck Institute for Polymer Research (MPIP), Mainz (D). In his interdisciplinary research, Frederik designs polymeric materials with molecular-defined functions. Controlling the monomer sequence and chemical functionality allowed designing materials for degradable polymers, nanocarriers with controlled blood interactions, and phosphorus flame-retardants. He has published more than 150 research articles to date. He was awarded the Reimund Stadler Award in 2016, the Lecturer Award of the German Chemical Industry Fund in 2017, the European Young Chemist Award and the Georg Manecke Prize of the German Chemical Society in 2014. Frederik received his PhD in 2009 (JGU Mainz, D). After a two-year stay at EPFL (CH) as a Humboldt fellow, he joined the department "Physical Chemistry of Polymers" at MPIP and finished his habilitation in Macromolecular Chemistry in 2016.
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0306-0012
1460-4744
DOI:10.1039/c8cs00531a