6-Hydroxymethyl-1-phenazine-carboxamide and 1,6-phenazinedimethanol from a marine bacterium, Brevibacterium sp. KMD 003, associated with marine purple vase sponge

• Published in: Journal of antibiotics Vol. 62; no. 11; pp. 621 - 624
• Main Authors: Choi, Eun Ju, Kwon, Hak Cheol, Ham, Jungyeob, Yang, Hyun Ok
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.11.2009; Japan Antibiotics Research Assoc; Nature Publishing Group
• Subjects: Animals; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - isolation & purification; Anti-Bacterial Agents - pharmacology; Bacteriology; Biomedical and Life Sciences; Bioorganic Chemistry; Biotechnology & Applied Microbiology; Brevibacterium - metabolism; Callyspongia - microbiology; Immunology; Life Sciences; Life Sciences & Biomedicine; Magnetic Resonance Spectroscopy; Medicinal Chemistry; Microbiology; Organic Chemistry; original-article; Pharmacology & Pharmacy; Phenazines - chemistry; Phenazines - isolation & purification; Phenazines - pharmacology; Science & Technology; antibacterial activity; sponge; phenazine; 1,6-phenazinedimethanol; 6-Hydroxymethyl-1-phenazine-carboxamide; METABOLITES; ACID; antibacterial activity; Brevibacterium; 6-Hydroxymethyl-1-phenazine-carboxamide; phenazine; CALLYSPONGIA-TRUNCATA; IN-VITRO; PSEUDOMONAS-AERUGINOSA; BIOSYNTHESIS; PHENAZINE ANTIBIOTICS; STRAIN; PYOCYANIN
• ISSN: 0021-8820; 1881-1469
• DOI: 10.1038/ja.2009.92

Two new antibacterial phenazines were isolated from the culture broth of Brevibacterium sp. KMD 003 obtained from a marine purple vase sponge of the genus Callyspongia , collected in Kyeongpo, Gangwondo, Korea. The structures of these compounds were determined to be 6-hydroxymethyl-1-phenazine-carboxamide ( 1 ) and 1,6-phenazinedimethanol ( 2 ) through analyses of HR–EI–MS and NMR data. Compounds 1 and 2 showed antibacterial activities against Enterococcus hirae and Micrococcus luteus with 5  μ M MIC values.