Osteoarthritis Disease Severity in the Temporomandibular Joint and the Knee Joint: A Comparative Cadaveric Study

• Published in: Cartilage Vol. 14; no. 4; pp. 445 - 454
• Main Authors: Immonen, Jessica A., Ciccotelli, Jason, Nguyen, Linh M., Gilmer, Lesley, Broadhead, Landen, Kitchen, Mackenzie, Paul, Conner, James, Jeremy
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA SAGE Publications 01.12.2023
• Subjects: Cadaver; Clinical Research; Female; Humans; Knee Joint - pathology; Male; Osteoarthritis - pathology; Patient Acuity; Temporomandibular Joint; Temporomandibular Joint Disorders - pathology; articular cartilage; diagnosis; tissue; temporomandibular joint; osteoarthritis; knee joint
• ISSN: 1947-6035; 1947-6043; 1947-6043
• DOI: 10.1177/19476035231189839

Objective The objective of this study was to determine the level of disease severity in a pilot cohort of temporomandibular joints (TMJs) and compare them to the pathology findings previously characterized in cadaveric knee joints. Design Thirty-one intact TMJs from 17 cadaveric donors were harvested and arthritic lesioning seen in the knee joint was investigated on the condyle and the fossa of the TMJ. Prevalence of gross alterations was equated and disease severity was determined for sex- and age-based donor pools using a validated, osteoarthritis (OA) disease severity scale (DSS). Knee joint DSS scores were also compared to the TMJ condyle and fossa DSS scores and a case study was carried out on a male donor that demonstrated severe OA in the both joints. Results The mandibular fossa demonstrated an increase in disease severity compared to the mandibular condyle in a mixed sex donor pool (P = 0.035). It was discovered that the younger females demonstrated statistically more pathological condyles compared to the older half of the female subgroup (P = 0.02). TMJ fossa and knee joints demonstrated comparable OA severity and similar signs of cartilage disease in a single donor highlighting the systemic nature of OA. Conclusions This study demonstrates that gross signs of OA in the TMJs of cadavers are comparable to pathology found in the knee. The mandibular fossa appears to be the site of more profound disease, implying translational movements may be more likely to induce biomechanically abnormal movement, loading, and OA.