Decoding cis-regulatory DNAs in the Drosophila genome

• Published in: Current Opinion in Genetics & Development Vol. 12; no. 5; pp. 601 - 606
• Main Authors: Markstein, Michele, Levine, Michael
• Format: Book Review Journal Article
• Language: English
• Published: England Elsevier Ltd 01.10.2002
• Subjects: Animals; Binding Sites - genetics; Body Patterning - genetics; cis-regulatory; computational analysis; Computational Biology; DNA; Drosophila melanogaster - embryology; Drosophila melanogaster - genetics; Drosophila melanogaster - metabolism; enhancer; Genes, Insect; Genes, Regulator; Genome; metazoa; Multigene Family; Promoter Regions, Genetic; Regulatory Sequences, Nucleic Acid; Transcription Factors - metabolism; Transcription, Genetic; enhancer; DNA; metazoa; Development; Evolution; Genetics; cis-regulatory; computational analysis; Bioinformatics

Cis-regulatory DNAs control the timing and sites of gene expression during metazoan development. Changes in gene expression are responsible for the morphological diversification of metazoan body plans. However, traditional methods for the identification and characterization of cis-regulatory DNAs ar...